MCM6 and SCNM1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MCM6	SCNM1
Description		minichromosome maintenance complex component 6	sodium channel modifier 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex	Nucleus Nuclear Speck
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Identical Protein Binding Single-stranded DNA-dependent ATP-dependent 3'-5' DNA Helicase Activity	Protein Binding Enzyme Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication	Alternative MRNA Splicing, Via Spliceosome RNA Splicing
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Body mass index ( 25673413) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		36 interacting genes: C2CD6 CCNA1 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 UBE3A ZBTB9	48 interacting genes: BLZF1 CBY2 CCDC33 CCDC85B CDR2 CEP44 COG6 DVL2 GOLGA2 HMG20A IKZF1 INCA1 KRT31 KRT38 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 LNX2 LZTS2 MCM6 MEOX2 MID2 MIPOL1 MKRN3 MTUS2 NAB2 NOTCH2NLA PDE4DIP PLSCR1 PNMA1 PNMA2 PRNP RINT1 RPGRIP1 SSX2IP SYCE1 TFIP11 TLE5 TRAF1 TRIM27 TRIM37 TRIM42 TRIM54 UBXN11 ZBTB14 ZDHHC17
Entrez ID		4175	79005
HPRD ID		03485	12162
Ensembl ID		ENSG00000076003	ENSG00000163156
Uniprot IDs		Q14566	Q9BWG6
PDB IDs		2KLQ 2LE8
Enriched GO Terms of Interacting Partners?
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