MCM6 and SNRPB2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MCM6	SNRPB2
Description		minichromosome maintenance complex component 6	small nuclear ribonucleoprotein polypeptide B2
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GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex	Fibrillar Center Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP U2 SnRNP Nuclear Speck Cytoplasmic Ribonucleoprotein Granule U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Identical Protein Binding Single-stranded DNA-dependent ATP-dependent 3'-5' DNA Helicase Activity	Protein Binding U1 SnRNA Binding SnRNP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication	MRNA Splicing, Via Spliceosome
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 25673413) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Food allergy (maternal genetic effects) ( 29489655) Metabolite levels ( 23823483) Response to haloperidol in schizophrenia ( 29503163)
Interacting Genes		36 interacting genes: C2CD6 CCNA1 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 UBE3A ZBTB9	17 interacting genes: CALM1 CSDE1 DHX9 GABPB1 GOLGA2 HMBOX1 HNRNPUL1 HOMEZ HTATSF1 MCM6 MTUS2 PNMA1 SMN2 SNRPA1 SUGP1 TRIM27 ZBTB14
Entrez ID		4175	6629
HPRD ID		03485	04628
Ensembl ID		ENSG00000076003	ENSG00000125870
Uniprot IDs		Q14566	P08579
PDB IDs		2KLQ 2LE8	1A9N 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QX9
Enriched GO Terms of Interacting Partners?
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