MBP and STK26

Number of citations of the paper that reports this interaction (PubMedID 11641781)
30

Data Source:
HPRD (in vivo, in vitro)

		MBP	STK26
Description		myelin basic protein	serine/threonine kinase 26
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery	Golgi Membrane Cytoplasm Golgi Apparatus Golgi-associated Vesicle Cytosol Vesicle Membrane Membrane Apical Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Permeability Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Interleukin-6 Secretion	Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Cellular Response To Starvation Signal Transduction By Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Response To Hydrogen Peroxide Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Apoptotic cleavage of cellular proteins
Drugs			[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)	Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		72 interacting genes: ABL1 APTX ATN1 ATXN1 BMP2K CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTPRA RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1	12 interacting genes: APP CEP76 GOLGA2 GRB14 IKZF3 MBP NEDD4 PDCD10 RAF1 SRPK1 TRAF6 TRIM27
Entrez ID		4155	51765
HPRD ID		01158	06663
Ensembl ID		ENSG00000197971	ENSG00000134602
Uniprot IDs		A0A024R384 P02686	Q9P289
PDB IDs		1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL	3GGF 3W8I 4FZA 4FZD 4FZF 4GEH 5XY9 5YF4
Enriched GO Terms of Interacting Partners?
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