SMAD7 and ASH1L

Number of citations of the paper that reports this interaction (PubMedID 15231748)
85

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SMAD7	ASH1L
Description		SMAD family member 7	ASH1 like histone lysine methyltransferase
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GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Catenin Complex Protein-containing Complex	Nucleus Nucleoplasm Chromosome Golgi Apparatus Bicellular Tight Junction
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Collagen Binding Beta-catenin Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Activin Binding I-SMAD Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Ossification Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein-containing Complex Localization Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation	Skeletal System Development Negative Regulation Of Acute Inflammatory Response DNA Packaging Transcription By RNA Polymerase II Cell-cell Signaling Single Fertilization Post-embryonic Development Flagellated Sperm Motility Interleukin-6 Production Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Decidualization Histone H3-K9 Methylation Histone H3-K4 Methylation Uterus Morphogenesis Histone H3-K36 Dimethylation Tarsal Gland Development Uterine Gland Development
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 25990418 18372901 18372905 30529582 21761138 17934461 26151821 29228715 30104761 24836286 29471430 24448986 23266556) Colorectal cancer or advanced adenoma ( 30510241) Creatinine levels ( 29403010) Dental caries ( 23064961) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Inflammatory bowel disease ( 23128233) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 27863252)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Crohn's disease ( 28067908) Dementia with Lewy bodies ( 31065058) Inflammatory bowel disease ( 28067908) Nickel levels ( 26025379) Non-cardia gastric cancer ( 26701879)
Interacting Genes		59 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L OTUD1 PARD3 PIAS1 PIAS4 RLIM RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107	2 interacting genes: H3C1 SMAD7
Entrez ID		4092	55870
HPRD ID		04241	06416
Ensembl ID		ENSG00000101665	ENSG00000116539
Uniprot IDs		B3KYA8 O15105	Q9NR48
PDB IDs		2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ	3MQM 3OPE 4YNM 4YNP 4YPA 4YPE 4YPU 6AGO 6INE
Enriched GO Terms of Interacting Partners?
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