MXD1 and MYCN

Number of citations of the paper that reports this interaction (PubMedID 11602341)
65

Data Source:
HPRD (in vitro, in vivo)

		MXD1	MYCN
Description		MAX dimerization protein 1	MYCN proto-oncogene, bHLH transcription factor
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Dimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways
Drugs
Diseases			Neuroblastoma Feingold syndrome
GWAS		Carotid plaque burden (smoking interaction) ( 24954085) High light scatter reticulocyte count ( 27863252) Mean platelet volume ( 27863252) Platelet count ( 27863252) Red cell distribution width ( 28957414)	Asthma or chronic obstructive pulmonary disease ( 24993907) Basal cell carcinoma ( 25855136) Height ( 31562340) Metabolite levels ( 23823483) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Pulmonary function (smoking interaction) ( 23284291) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Wilms tumor ( 22544364)
Interacting Genes		19 interacting genes: AKT1 APP CD2 HDAC1 HDAC2 MAX MLX MOGS MYC MYCL MYCN PML PRAM1 RPS6KA1 RPS6KB1 SAP30 SIN3A SIN3B SMC3	20 interacting genes: CSNK2A1 CSNK2A2 DOT1L EZH2 FBXW7 GRSF1 HUWE1 MAX MXD1 NEDD4 NMI NONO RUNX3 SIRT1 SP1 TRIM32 YAF2 YBX1 YEATS4 ZBTB17
Entrez ID		4084	4613
HPRD ID		02487	01278
Ensembl ID		ENSG00000059728	ENSG00000134323
Uniprot IDs		B7ZLI7 Q05195	A0A1W2PPD9 P04198 Q9H224
PDB IDs		1E91 1G1E 1NLW 1PD7 1S5Q	5G1X
Enriched GO Terms of Interacting Partners?
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