MYCN and NMI

Number of citations of the paper that reports this interaction (PubMedID 8668343)
24

Data Source:
HPRD (two hybrid, in vivo)

		MYCN	NMI
Description		MYCN proto-oncogene, bHLH transcription factor	N-myc and STAT interactor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Nucleolus	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Dimerization Activity	Transcription Coregulator Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Transcription By RNA Polymerase II Inflammatory Response JAK-STAT Cascade Negative Regulation Of Interferon-alpha Biosynthetic Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Innate Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein K48-linked Ubiquitination Regulation Of Nucleic Acid-templated Transcription
Pathways
Drugs
Diseases		Neuroblastoma Feingold syndrome
GWAS		Asthma or chronic obstructive pulmonary disease ( 24993907) Basal cell carcinoma ( 25855136) Height ( 31562340) Metabolite levels ( 23823483) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Pulmonary function (smoking interaction) ( 23284291) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Wilms tumor ( 22544364)	Blood protein levels ( 28240269)
Interacting Genes		20 interacting genes: CSNK2A1 CSNK2A2 DOT1L EZH2 FBXW7 GRSF1 HUWE1 MAX MXD1 NEDD4 NMI NONO RUNX3 SIRT1 SP1 TRIM32 YAF2 YBX1 YEATS4 ZBTB17	54 interacting genes: BRCA1 BRMS1 C1orf216 C9orf72 CDKN2A CDKN2D CNKSR3 CNOT7 COPS7B CYP2E1 EMILIN1 EXOSC5 GCSH GOLGA8EP HDDC3 HGS HHLA3 HOXC9 HSPA8 HSPH1 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MCPH1 MORF4L1 MTMR6 MTMR9 MYC MYCN NECAP2 POMZP3 PSMA1 RYBP SCEL SFR1 SH3GLB2 SINHCAF SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 TRAF5 TRIP12 TUBA3C TUBA3E TXLNA TXLNB UBE2I
Entrez ID		4613	9111
HPRD ID		01278	04632
Ensembl ID		ENSG00000134323	ENSG00000123609
Uniprot IDs		A0A1W2PPD9 P04198 Q9H224	Q13287
PDB IDs		5G1X
Enriched GO Terms of Interacting Partners?
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