LHX1 and OTX2

Number of citations of the paper that reports this interaction (PubMedID 10623575)
13

Data Source:
BioGRID (pull down)

		LHX1	OTX2
Description		LIM homeobox 1	orthodenticle homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Protein-containing Complex	Nuclear Chromatin Nucleus Growth Cone Protein-containing Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Eukaryotic Initiation Factor 4E Binding
	Biological Process	Urogenital System Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Gastrulation With Mouth Forming Second Ectoderm Formation Endoderm Formation Kidney Development Transcription By RNA Polymerase II Cell-cell Signaling Pattern Specification Process Nervous System Development Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Post-embryonic Development Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Regulation Of Gene Expression Retina Layer Formation Ventral Spinal Cord Development Spinal Cord Association Neuron Differentiation Telencephalon Development Cerebellum Development Cerebellar Purkinje Cell Differentiation Forebrain Regionalization Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Neuron Differentiation Somite Rostral/caudal Axis Specification Metanephric Part Of Ureteric Bud Development Oviduct Epithelium Development Uterine Epithelium Development Nephric Duct Elongation Horizontal Cell Localization Positive Regulation Of Embryonic Development Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Anatomical Structure Formation Involved In Morphogenesis Embryonic Viscerocranium Morphogenesis Pronephros Development Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Oviduct Development Cervix Development Vagina Development Head Development Epithelium Development Paramesonephric Duct Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Vesicle Morphogenesis Mesonephric Duct Development Nephric Duct Morphogenesis Ureter Morphogenesis Metanephric Glomerulus Development Metanephric Comma-shaped Body Morphogenesis Metanephric Renal Vesicle Morphogenesis Metanephric S-shaped Body Morphogenesis Primitive Streak Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Dorsal Spinal Cord Interneuron Posterior Axon Guidance Lateral Motor Column Neuron Migration Positive Regulation Of Gastrulation Positive Regulation Of Anterior Head Development Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation	Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation
Pathways
Drugs
Diseases			Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Alzheimer's disease ( 30636644) Body mass index ( 26426971) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Moderate-to-late spontaneous preterm birth ( 31194736)
Interacting Genes		5 interacting genes: FOXA2 ISL1 LHX3 OTX2 RLIM	10 interacting genes: APP ATXN1 CDK4 DMBX1 FOXA2 LHX1 MITF SMARCB1 TLE4 ZDHHC17
Entrez ID		3975	5015
HPRD ID		09067	07190
Ensembl ID		ENSG00000273706	ENSG00000165588
Uniprot IDs		P48742 Q58F18	F1T0C9 F1T0D0 F1T0D1 P32243
PDB IDs
Enriched GO Terms of Interacting Partners?
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