LHX1 and ISL1

Number of citations of the paper that reports this interaction (PubMedID 9452425)
54

Data Source:
HPRD (in vivo)

		LHX1	ISL1
Description		LIM homeobox 1	ISL LIM homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Protein-containing Complex	Nuclear Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Estrogen Receptor Binding BHLH Transcription Factor Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Urogenital System Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Gastrulation With Mouth Forming Second Ectoderm Formation Endoderm Formation Kidney Development Transcription By RNA Polymerase II Cell-cell Signaling Pattern Specification Process Nervous System Development Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Post-embryonic Development Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Regulation Of Gene Expression Retina Layer Formation Ventral Spinal Cord Development Spinal Cord Association Neuron Differentiation Telencephalon Development Cerebellum Development Cerebellar Purkinje Cell Differentiation Forebrain Regionalization Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Neuron Differentiation Somite Rostral/caudal Axis Specification Metanephric Part Of Ureteric Bud Development Oviduct Epithelium Development Uterine Epithelium Development Nephric Duct Elongation Horizontal Cell Localization Positive Regulation Of Embryonic Development Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Anatomical Structure Formation Involved In Morphogenesis Embryonic Viscerocranium Morphogenesis Pronephros Development Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Oviduct Development Cervix Development Vagina Development Head Development Epithelium Development Paramesonephric Duct Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Vesicle Morphogenesis Mesonephric Duct Development Nephric Duct Morphogenesis Ureter Morphogenesis Metanephric Glomerulus Development Metanephric Comma-shaped Body Morphogenesis Metanephric Renal Vesicle Morphogenesis Metanephric S-shaped Body Morphogenesis Primitive Streak Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Dorsal Spinal Cord Interneuron Posterior Axon Guidance Lateral Motor Column Neuron Migration Positive Regulation Of Gastrulation Positive Regulation Of Anterior Head Development Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Axonogenesis Heart Development Positive Regulation Of Cell Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial To Mesenchymal Transition Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Negative Regulation Of Protein Complex Assembly Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Histone Acetylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Mesenchymal Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Macrophage Colony-stimulating Factor Production
Pathways			Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644) Body mass index ( 26426971) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Alcohol use disorder (consumption score) ( 30940813) Automobile speeding propensity ( 30643258) Childhood ear infection ( 27182965) Classic bladder exstrophy ( 25763902) Dental caries ( 23259602) Diastolic blood pressure ( 27841878) Emotional lability in attention deficit hyperactivity disorder ( 31085060) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Verbal declarative memory ( 25648963) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		5 interacting genes: FOXA2 ISL1 LHX3 OTX2 RLIM	21 interacting genes: APP CDK6 CDKN2B CRK ESR1 HNF4A ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LMO2 LMX1A NR2F1 PECR PLCG2 RELA RLIM SMAD3 ZNF511
Entrez ID		3975	3670
HPRD ID		09067	02650
Ensembl ID		ENSG00000273706	ENSG00000016082
Uniprot IDs		P48742 Q58F18	P61371
PDB IDs
Enriched GO Terms of Interacting Partners?
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