LDHA and KCNJ11

Number of citations of the paper that reports this interaction (PubMedID 12145195)
42

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		LDHA	KCNJ11
Description		lactate dehydrogenase A	potassium inwardly rectifying channel subfamily J member 11
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GO Annotations	Cellular Component	Nucleus Cytosol Membrane Extracellular Exosome	Acrosomal Vesicle Cell Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Inward Rectifying Potassium Channel Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber
	Molecular Function	L-lactate Dehydrogenase Activity Protein Binding Kinase Binding Identical Protein Binding Cadherin Binding NAD Binding	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity Cation-transporting ATPase Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Ion Channel Binding
	Biological Process	Response To Hypoxia Lactate Metabolic Process Pyruvate Metabolic Process Glycolytic Process Response To Nutrient Response To Glucose NAD Metabolic Process Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Post-embryonic Animal Organ Development Response To CAMP Oxidation-reduction Process	Response To Ischemia Glucose Metabolic Process Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Response To Drug Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process Transmembrane Transport Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane Positive Regulation Of Cation Channel Activity
Pathways		Pyruvate metabolism	ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia Defective ABCC8 can cause hypoglycemias and hyperglycemias
Drugs		NADH Etheno-Nad Nicotinamide Oxamic Acid Stiripentol Copper Artenimol	Glimepiride Ibutilide Verapamil Tolazamide Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine
Diseases			Type II diabetes mellitus Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Amyloid A serum levels ( 21124955)	Body mass index ( 26426971 28892062 25673413 29273807) Mean arterial pressure ( 27618448) Medication use (drugs used in diabetes) ( 31015401) Pulse pressure ( 27618448 30578418) Social communication problems ( 24564958) Systolic blood pressure ( 27618448 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes ( 22885922 18372903 24509480 30054458 29358691 30297969 29632382 31118516 17463246 30718926 17463248 17463249 28869590 19056611) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		16 interacting genes: ABCC9 ACD DYNLL1 HNRNPD KCNJ11 LDHB MAPK10 NDRG1 PCNA POT1 PTPRF TERF1 TINF2 UPF2 XRN1 YWHAQ	6 interacting genes: ABCC8 ABCC9 AP2M1 KCNJ2 KCNJ8 LDHA
Entrez ID		3939	3767
HPRD ID		01025	09022
Ensembl ID		ENSG00000134333	ENSG00000187486
Uniprot IDs		P00338 V9HWB9	B2RC52 Q14654
PDB IDs		1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY 5W8H 5W8I 5W8J 5W8K 5W8L 5ZJD 5ZJE 5ZJF 6BAD 6BAG 6BAX 6BAZ 6BB0 6BB1 6BB2 6BB3 6MV8 6MVA	6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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