KCNJ11 and KCNJ8

Number of citations of the paper that reports this interaction (PubMedID 11136227)
33

Data Source:
HPRD (in vivo, in vitro)

		KCNJ11	KCNJ8
Description		potassium inwardly rectifying channel subfamily J member 11	potassium inwardly rectifying channel subfamily J member 8
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cell Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Inward Rectifying Potassium Channel Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber	Plasma Membrane Voltage-gated Potassium Channel Complex Potassium Ion-transporting ATPase Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity Cation-transporting ATPase Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Ion Channel Binding	Inward Rectifier Potassium Channel Activity ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Cation-transporting ATPase Activity Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Response To Ischemia Glucose Metabolic Process Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Response To Drug Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process Transmembrane Transport Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane Positive Regulation Of Cation Channel Activity	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Potassium Ion Import Across Plasma Membrane
Pathways		ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia Defective ABCC8 can cause hypoglycemias and hyperglycemias	ATP sensitive Potassium channels
Drugs		Glimepiride Ibutilide Verapamil Tolazamide Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine	Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine
Diseases		Type II diabetes mellitus Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Body mass index ( 26426971 28892062 25673413 29273807) Mean arterial pressure ( 27618448) Medication use (drugs used in diabetes) ( 31015401) Pulse pressure ( 27618448 30578418) Social communication problems ( 24564958) Systolic blood pressure ( 27618448 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes ( 22885922 18372903 24509480 30054458 29358691 30297969 29632382 31118516 17463246 30718926 17463248 17463249 28869590 19056611) Type 2 diabetes (adjusted for BMI) ( 29632382)	Birth weight ( 31043758)
Interacting Genes		6 interacting genes: ABCC8 ABCC9 AP2M1 KCNJ2 KCNJ8 LDHA	4 interacting genes: ABCC8 ABCC9 KCNJ11 KCNJ2
Entrez ID		3767	3764
HPRD ID		09022	02962
Ensembl ID		ENSG00000187486	ENSG00000121361
Uniprot IDs		B2RC52 Q14654	A0A024RAV6 Q15842
PDB IDs		6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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