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NOTCH2NLA and CDK5R1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
381
Data Source:
BioGRID
(two hybrid)
NOTCH2NLA
CDK5R1
Description
notch 2 N-terminal like A
cyclin dependent kinase 5 regulatory subunit 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Perikaryon
Intracellular Membrane-bounded Organelle
Contractile Fiber
Perinuclear Region Of Cytoplasm
Presynapse
Molecular Function
Notch Binding
Calcium Ion Binding
Protein Binding
Protease Binding
Protein Kinase Activity
Calcium Ion Binding
Protein Binding
Kinase Activity
Protein Kinase Binding
Protein Kinase Activator Activity
Ionotropic Glutamate Receptor Binding
Alpha-tubulin Binding
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
Ephrin Receptor Binding
Beta-tubulin Binding
Actin Filament Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
Notch Signaling Pathway
Cerebral Cortex Development
Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Microtubule Cytoskeleton Organization
Neuron Migration
Neuron Cell-cell Adhesion
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Axon Guidance
Axonal Fasciculation
Brain Development
Embryo Development Ending In Birth Or Egg Hatching
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cerebellum Development
Superior Olivary Nucleus Maturation
Hippocampus Development
Layer Formation In Cerebral Cortex
Neuron Differentiation
Negative Regulation Of Axon Extension
Positive Regulation Of Microtubule Polymerization
Neuron Projection Development
Activation Of Protein Kinase Activity
Regulation Of Actin Cytoskeleton Organization
Ionotropic Glutamate Receptor Signaling Pathway
Serine Phosphorylation Of STAT Protein
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Ephrin Receptor Signaling Pathway
Rhythmic Process
Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Synaptic Vesicle Cycle
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
Drugs
Indirubin-3'-Monoxime
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Interacting Genes
242 interacting genes:
ACY3
ADAMTSL3
ADAMTSL5
ADCK5
ALDH3B1
ALPI
AQP1
AQP5
ARID3A
ASPSCR1
ATG9A
BCL6B
BLCAP
BMP7
C11orf87
C5orf60
CA6
CARHSP1
CATSPER1
CCDC26
CCDC93
CCER1
CD164
CDK5R1
CERK
CHCHD3
CHDH
CHIC2
CHRD
CHRNG
CLDN2
CLEC18A
COL8A1
CRACR2A
CRCT1
CREB5
CSF1
CST2
CST9L
CTSG
CTSZ
CXCL16
CXCL5
DGCR6
DHRS1
DMRT3
DNAL4
DOCK2
EFNA3
EIF4E2
ELANE
EPHB6
ESR2
FAAH
FAM124B
FAM71C
FAM71E2
FAM74A4
FARS2
FASLG
FBXL18
FBXW5
FOXB1
FRS3
GABRD
GATA2
GEM
GFOD1
GIP
GLP1R
GLRX3
GLYAT
GNAI2
GNE
GNMT
GSTP1
GTF3C5
H2AC15
HBZ
HCK
HOXA1
HPCAL1
HSBP1
HSD3B7
HSPA12B
HSPBP1
HSPD1
ICAM4
IFI30
IL2RG
INPP5D
ITGB2
ITGB5
JOSD1
KCTD15
KIF1A
KLHL38
KLK8
KRT20
KRT83
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-4
KRTAP13-3
KRTAP26-1
KRTAP3-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LCE1B
LCE2D
LCE3C
LCE3E
LIMS2
LIN7A
LINC00526
LINC00656
LMO2
LNX1
LONRF3
LRCH4
LRFN4
MAPKBP1
MARK4
MATN3
MELTF
MRGBP
MRPL40
MTA1
MVP
MXD3
MXI1
NAB2
NAXD
NECTIN2
NECTIN3
NEU2
NMU
NMUR2
NPBWR2
NPDC1
NPPB
NR1D2
NUBP2
P2RX4
PCED1A
PCED1B
PCSK5
PDE9A
PGLS
PID1
PIGS
PLPP2
PLSCR4
POLR2G
POM121L8P
POMGNT2
PRKAA2
PRPF31
PRPS2
PSMA1
PSMG2
PTGER3
PTPMT1
PTPN23
PVR
QPRT
R3HDM2
RAB3IL1
RAMP3
RCHY1
RECK
RET
RGL2
RPS28
RTN4RL1
SCNM1
SDCBP
SELENOM
SEMA4C
SHFL
SLC22A23
SLC23A1
SLC25A10
SLC25A6
SLC6A20
SMARCD2
SMARCE1
SMCP
SMOC1
SNAI1
SPATA8
SPG7
SPINK2
SPRY1
STK16
TBC1D10C
TBC1D16
TEDC2
THAP7
THEMIS2
TINAGL1
TLE5
TMEM150A
TMEM231
TMEM41A
TNIP3
TNK2
TNP2
TRIM27
TRIM42
TRPV6
TSPAN4
TXNDC5
UBQLN4
UTP23
UXT
WDR25
WT1-AS
XCL2
YIPF3
ZFYVE21
ZNF124
ZNF32
ZNF417
ZNF439
ZNF440
ZNF446
ZNF581
ZNF587
ZNF688
30 interacting genes:
ACTN1
AMPH
APP
BLOC1S6
CAMK2A
CAPN1
CAPN2
CDK16
CDK5
CDK5RAP1
CDK5RAP2
CDK5RAP3
CDK9
CHN1
CTNNB1
HSP90AA1
KRT40
KRTAP10-3
LMTK2
MTUS2
NEDD4
NES
NOTCH2NLA
ODF1
PAK1
SET
SIAH1
STXBP1
TSC22D4
TTBK1
Entrez ID
388677
8851
HPRD ID
14833
04586
Ensembl ID
ENSG00000264343
ENSG00000176749
Uniprot IDs
P0DPK4
Q7Z3S9
Q15078
Q8N619
PDB IDs
1H4L
1UNG
1UNH
1UNL
3O0G
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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