NOTCH2NLA and GLRX3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NOTCH2NLA	GLRX3
Description		notch 2 N-terminal like A	glutaredoxin 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Cell Nucleus Cytosol Cell Cortex Z Disc Dendrite
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding	RNA Binding Protein Kinase C Binding Protein Binding Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding
	Biological Process	Notch Signaling Pathway Cerebral Cortex Development Cell Differentiation Positive Regulation Of Notch Signaling Pathway	Regulation Of The Force Of Heart Contraction Cellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy Electron Transport Chain [2Fe-2S] Cluster Assembly Cell Redox Homeostasis Protein Maturation By Iron-sulfur Cluster Transfer
Pathways			Iron uptake and transport
Drugs
Diseases
GWAS			Alcohol dependence ( 26365420) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		242 interacting genes: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C5orf60 CA6 CARHSP1 CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 H2AC15 HBZ HCK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MELTF MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NAXD NECTIN2 NECTIN3 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLPP2 PLSCR4 POLR2G POM121L8P POMGNT2 PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELENOM SEMA4C SHFL SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 TEDC2 THAP7 THEMIS2 TINAGL1 TLE5 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587 ZNF688	69 interacting genes: ADAMTSL4 ALKBH3 BCL6 BOLA1 CA9 CBLB CCHCR1 CGGBP1 CIAPIN1 EFEMP2 FAM118A FRA10AC1 GATA1 GMCL1 GRN HEXD IHO1 IKZF1 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE2D LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI MOXD1 NADK NOTCH2NLA OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ PRKD2 RGS20 SOX7 STAU1 TCF4 TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF148 ZNF23 ZNF426 ZNF512B ZNF544
Entrez ID		388677	10539
HPRD ID		14833	10153
Ensembl ID		ENSG00000264343	ENSG00000108010
Uniprot IDs		P0DPK4 Q7Z3S9	A0A140VJK1 O76003
PDB IDs			2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?
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