INCA1 and VPS28

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		INCA1	VPS28
Description		inhibitor of CDK, cyclin A1 interacting protein 1	VPS28 subunit of ESCRT-I
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	ESCRT I Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Late Endosome Membrane Host Cell Extracellular Exosome
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding Protein-containing Complex Binding	Protein Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway	Endosomal Transport Macroautophagy Viral Life Cycle Negative Regulation Of Protein Ubiquitination Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Intracellular Transport Of Virus Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways			Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Intraocular pressure ( 29235454) Obesity-related traits ( 23251661)	Blood metabolite levels ( 26401656) Educational attainment ( 25201988)
Interacting Genes		39 interacting genes: ARMC7 CABP5 CCNA1 CDC23 CDK2 CDKN2D CHCHD2 COL8A1 CTNNBIP1 DAZAP2 DMRT3 DPH7 EPHB6 FHL2 FMR1 GRB2 HAUS1 NEK6 OSGIN1 PATE1 PTGER3 RAB5C RAMAC RBPMS RNF26 SAP18 SCNM1 SEC14L4 SPG21 SPOUT1 STAMBPL1 STK16 TRIM26 TRIP6 UBE2D4 UBXN2B VPS28 ZMYND19 ZNF205-AS1	30 interacting genes: ASF1A BLZF1 CARD9 CBX5 CEP57L1 FABP3 GABARAP GLCCI1 GOLGA2 INCA1 MBIP PDCD6IP PNMA5 RASSF5 SAXO1 SKIL SMN1 SMN2 TCF12 TCF4 TRIM27 TRIM54 TSG101 UBA52 UBC USHBP1 VPS37A VPS37B VPS37C VPS52
Entrez ID		388324	51160
HPRD ID		17150	11675
Ensembl ID		ENSG00000196388	ENSG00000160948
Uniprot IDs		Q0VD86	A0A0S2Z5H5 Q548N1 Q9UK41
PDB IDs
Enriched GO Terms of Interacting Partners?
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