IPO5 and RPL5

Number of citations of the paper that reports this interaction (PubMedID 9687515)
166

Data Source:
HPRD (in vitro)

		IPO5	RPL5
Description		importin 5	ribosomal protein L5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleolus Cytoplasm Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Protein-containing Complex Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	RNA Binding GTPase Inhibitor Activity Protein Binding Nuclear Localization Sequence Binding Ran GTPase Binding Nuclear Import Signal Receptor Activity	RNA Binding MRNA 3'-UTR Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Ubiquitin Protein Ligase Binding MRNA 5'-UTR Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Viral Process Negative Regulation Of GTPase Activity Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Amino Acid Stimulus	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Gene Expression Viral Transcription Ribosomal Large Subunit Biogenesis Positive Regulation Of Translation Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation
Pathways		vRNP Assembly	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases			Diamond-Blackfan anemia (DBA)
GWAS		Peripheral artery disease ( 26488411) Smooth-surface caries ( 24556642)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Height ( 20881960) Multiple sclerosis ( 19525955 17660530)
Interacting Genes		23 interacting genes: ACD BHLHB9 DPPA3 DTNBP1 H1-0 NUP153 NUP214 NUP62 NUP98 RAG2 RAN RANBP2 RPL13 RPL23 RPL23A RPL5 RPL7 RPS7 SRP19 SUMO2 TERF1 TINF2 WASL	24 interacting genes: CLK1 CSNK2A1 CSNK2B DCC EIF5A HARS1 IPO13 IPO5 IPO7 KPNB1 MAP3K14 MDM2 NVL PDCD4 PPM1D RNA5S7 SPIN1 SPP1 TNIP1 TNPO1 TP73 TSC22D1 UPF2 VHL
Entrez ID		3843	6125
HPRD ID		03597	04699
Ensembl ID		ENSG00000065150	ENSG00000122406
Uniprot IDs		B3KWG6 O00410 Q9BVS9	A2RUM7 P46777
PDB IDs			4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?