KLRD1 and HLA-G

Number of citations of the paper that reports this interaction (PubMedID 9405670)
7

Data Source:
HPRD (in vivo)

		KLRD1	HLA-G
Description		killer cell lectin like receptor D1	major histocompatibility complex, class I, G
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Golgi Membrane Extracellular Space Early Endosome Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Filopodium Membrane Early Endosome Membrane Cis-Golgi Network Membrane MHC Class I Protein Complex Recycling Endosome Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Carbohydrate Binding Protein Antigen Binding	Signaling Receptor Binding Protein Binding Peptide Antigen Binding CD8 Receptor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Natural Killer Cell Mediated Immunity Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response Cellular Defense Response Negative Regulation Of Angiogenesis Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of Protein Kinase B Signaling Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Negative Regulation Of G0 To G1 Transition Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of Dendritic Cell Differentiation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Umami taste perception in obesity with metabolic syndrome ( 31005965)	Autism spectrum disorder or schizophrenia ( 28540026) Childhood ear infection ( 27182965) Colorectal cancer ( 30529582) Crohn's disease ( 22412388) IgE levels ( 22075330) IgM levels ( 28628107) Lung adenocarcinoma ( 28604730) Non-albumin protein levels ( 29403010) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533)
Interacting Genes		6 interacting genes: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3	9 interacting genes: B2M CD8A COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2
Entrez ID		3824	3135
HPRD ID		04204	00834
Ensembl ID		ENSG00000134539	ENSG00000204632
Uniprot IDs		Q13241 Q53ZY6	P17693 Q31611 Q6DU14
PDB IDs		1B6E 3BDW 3CDG 3CII	1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO 6AEE 6K60
Enriched GO Terms of Interacting Partners?
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