HLA-G and LILRB1

Number of citations of the paper that reports this interaction (PubMedID 12853576)
113

Data Source:
HPRD (in vitro, in vivo)

		HLA-G	LILRB1
Description		major histocompatibility complex, class I, G	leukocyte immunoglobulin like receptor B1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Early Endosome Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Filopodium Membrane Early Endosome Membrane Cis-Golgi Network Membrane MHC Class I Protein Complex Recycling Endosome Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Peptide Antigen Binding CD8 Receptor Binding Identical Protein Binding Protein Homodimerization Activity	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity MHC Class Ib Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response Cellular Defense Response Negative Regulation Of Angiogenesis Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of Protein Kinase B Signaling Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Negative Regulation Of G0 To G1 Transition Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of Dendritic Cell Differentiation	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Proliferation Involved In Immune Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Receptor Internalization Interferon-gamma Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Interferon-beta Secretion Negative Regulation Of T Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Defense Response To Virus Negative Regulation Of Calcium Ion Transport Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Interferon-gamma Secretion Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Interleukin-12 Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of Osteoclast Development
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Childhood ear infection ( 27182965) Colorectal cancer ( 30529582) Crohn's disease ( 22412388) IgE levels ( 22075330) IgM levels ( 28628107) Lung adenocarcinoma ( 28604730) Non-albumin protein levels ( 29403010) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533)	Blood protein levels ( 30072576 29875488 28240269) Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		9 interacting genes: B2M CD8A COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2	6 interacting genes: B2M HLA-A HLA-B HLA-C HLA-F HLA-G
Entrez ID		3135	10859
HPRD ID		00834	07273
Ensembl ID		ENSG00000204632	ENSG00000104972
Uniprot IDs		P17693 Q31611 Q6DU14	A0A087WSV6 A0A087WSX8 A0A0B4J1W1 A8MVE2 D9IDM5 Q8NHL6
PDB IDs		1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO 6AEE 6K60	1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9 4NO0 5KNM 6EWA 6EWC 6EWO
Enriched GO Terms of Interacting Partners?
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