ACAT1 and PDP1

Number of citations of the paper that reports this interaction (PubMedID 24486017)
65

Data Source:
BioGRID (pull down)

		ACAT1	PDP1
Description		acetyl-CoA acetyltransferase 1	pyruvate dehyrogenase phosphatase catalytic subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Exosome	Mitochondrion Mitochondrial Matrix
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA C-acyltransferase Activity C-acetyltransferase Activity Enzyme Binding Identical Protein Binding Metal Ion Binding Coenzyme Binding	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Liver Development Acetyl-CoA Biosynthetic Process Isoleucine Catabolic Process Fatty Acid Beta-oxidation Brain Development Branched-chain Amino Acid Catabolic Process Response To Hormone Response To Organic Cyclic Compound Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Cholesterol Esterification Response To Starvation Acetyl-CoA Catabolic Process Ketone Body Biosynthetic Process Ketone Body Catabolic Process Adipose Tissue Development Metanephric Proximal Convoluted Tubule Development Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Peptidyl-threonine Dephosphorylation Positive Regulation Of Pyruvate Dehydrogenase Activity
Pathways		Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies	Regulation of pyruvate dehydrogenase (PDH) complex
Drugs		Sulfasalazine
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Nonunion in individuals with fractures ( 30680360)
Interacting Genes		4 interacting genes: AGXT PDP1 PEX7 PTPRF	8 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 PDHA1 PLEKHF2 PRKCD SIRT3
Entrez ID		38	54704
HPRD ID		01946	16185
Ensembl ID		ENSG00000075239	ENSG00000164951
Uniprot IDs		A0A140VJX1 A0A5F9ZHJ0 P24752	A0A024R9C0 Q6P1N1 Q9P0J1
PDB IDs		2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
Enriched GO Terms of Interacting Partners?
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