ACAT1 and AGXT

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ACAT1	AGXT
Description		acetyl-CoA acetyltransferase 1	alanine--glyoxylate and serine--pyruvate aminotransferase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Exosome	Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA C-acyltransferase Activity C-acetyltransferase Activity Enzyme Binding Identical Protein Binding Metal Ion Binding Coenzyme Binding	Serine-pyruvate Transaminase Activity Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity Protein Self-association
	Biological Process	Liver Development Acetyl-CoA Biosynthetic Process Isoleucine Catabolic Process Fatty Acid Beta-oxidation Brain Development Branched-chain Amino Acid Catabolic Process Response To Hormone Response To Organic Cyclic Compound Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Cholesterol Esterification Response To Starvation Acetyl-CoA Catabolic Process Ketone Body Biosynthetic Process Ketone Body Catabolic Process Adipose Tissue Development Metanephric Proximal Convoluted Tubule Development Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process	Protein Targeting To Peroxisome Notch Signaling Pathway Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process Cellular Nitrogen Compound Metabolic Process L-alanine Catabolic Process Pyruvate Biosynthetic Process Glyoxylate Metabolic Process Oxalic Acid Secretion Response To Glucocorticoid Response To CAMP
Pathways		Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies	Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs		Sulfasalazine	Pyridoxal Phosphate Serine Glycine L-Alanine Aminooxyacetic acid N'-Pyridoxyl-Lysine-5'-Monophosphate 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
Diseases			Primary hyperoxaluria (HP)
GWAS		Nonunion in individuals with fractures ( 30680360)	Blood metabolite levels ( 24816252) Height ( 25282103 31562340) Urinary metabolites ( 26352407)
Interacting Genes		4 interacting genes: AGXT PDP1 PEX7 PTPRF	4 interacting genes: ACAT1 GLP1R PEX5 SNCAIP
Entrez ID		38	189
HPRD ID		01946	05048
Ensembl ID		ENSG00000075239	ENSG00000172482
Uniprot IDs		A0A140VJX1 A0A5F9ZHJ0 P24752	P21549
PDB IDs		2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY	1H0C 1J04 2YOB 3R9A 4CBR 4CBS 4I8A 4KXK 4KYO 5F9S 5HHY 5LUC 5OFY 5OG0
Enriched GO Terms of Interacting Partners?
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