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KDR and TIMP3
Number of citations of the paper that reports this interaction (PubMedID
12652295
)
178
Data Source:
HPRD
(in vitro, in vivo)
KDR
TIMP3
Description
kinase insert domain receptor
TIMP metallopeptidase inhibitor 3
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Endosome
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Junction
Receptor Complex
Membrane Raft
Sorting Endosome
Extracellular Region
Basement Membrane
Extracellular Space
Nucleus
Extracellular Matrix
Platelet Dense Granule Lumen
Collagen-containing Extracellular Matrix
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor-activated Receptor Activity
Integrin Binding
Protein Binding
ATP Binding
Growth Factor Binding
Vascular Endothelial Growth Factor Binding
Identical Protein Binding
Cadherin Binding
Hsp90 Protein Binding
Protease Binding
Protein Binding
Metalloendopeptidase Inhibitor Activity
Metal Ion Binding
Biological Process
Angiogenesis
Vasculogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Sprouting Angiogenesis
Cell Migration Involved In Sprouting Angiogenesis
Endothelium Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Positive Regulation Of Cell Proliferation
Regulation Of Cell Shape
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Positive Regulation Of Macroautophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Kinase Activity
Embryonic Hemopoiesis
Calcium-mediated Signaling Using Intracellular Calcium Source
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Endothelial Cell Differentiation
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Mitochondrial Depolarization
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Mitochondrial Fission
Cellular Response To Hydrogen Sulfide
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Vasculogenesis
Platelet Degranulation
Visual Perception
Response To Hormone
Response To Organic Substance
Negative Regulation Of Endopeptidase Activity
Response To Cytokine
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Organic Substance
Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Negative Regulation Of Metalloendopeptidase Activity
Pathways
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Platelet degranulation
Drugs
Sorafenib
Sunitinib
N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA
Cediranib
Vatalanib
XL999
TG-100801
XL820
CYC116
Ramucirumab
ABT-869
IMC-1C11
Semaxanib
Pazopanib
Midostaurin
Axitinib
4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Foretinib
Pimagedine
Diseases
Sorsby fundus dystrophy
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Endometriosis (
28537267
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
)
Lung function (FVC) (
30804560
)
Mosquito bite size (
28199695
)
Peak expiratory flow (
30804560
)
Serum VEGFR2 concentration (
25411163
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
20385819
20385826
23455636
21665990
)
Alzheimer's disease progression score (
29860282
)
Blood protein levels (
30072576
28240269
)
Metabolite levels (
23823483
)
Pyoderma gangrenosum in inflammatory bowel disease (
24487271
)
Triglyceride levels (
31170924
)
Interacting Genes
61 interacting genes:
ACP1
AIMP2
ANXA5
ATR
BMX
BTRC
CAV1
CBL
CCDC88A
CDH5
COL18A1
CRK
CSF2RB
CSNK1D
CTNNB1
DNM2
DUSP19
FBXO25
FBXW11
FLT1
FLT4
FRS2
FYN
GABARAP
GNA11
GNAQ
GRB10
GRB2
HSP90AA1
ILKAP
IQGAP1
ITGB3
MAPK1
NCK1
NRP1
P2RY2
PDCL3
PLCG1
PLCG2
PPM1A
PPM1B
PTPN11
PTPN12
PTPN6
PTPRR
RASA1
SERPINF1
SH2D2A
SHB
SHC1
SHC2
SRC
SRP72
STAT1
STYX
SYNGAP1
TIMP3
VEGFA
VEGFC
VEGFD
YES1
8 interacting genes:
ADAM17
EFEMP1
KDR
MMP13
MMP14
MMP2
MMP3
MMP9
Entrez ID
3791
7078
HPRD ID
01867
01785
Ensembl ID
ENSG00000128052
ENSG00000100234
Uniprot IDs
P35968
P35625
PDB IDs
1VR2
1Y6A
1Y6B
1YWN
2M59
2MET
2MEU
2OH4
2P2H
2P2I
2QU5
2QU6
2RL5
2X1W
2X1X
2XIR
3B8Q
3B8R
3BE2
3C7Q
3CJF
3CJG
3CP9
3CPB
3CPC
3DTW
3EFL
3EWH
3KVQ
3S35
3S36
3S37
3U6J
3V2A
3V6B
3VHE
3VHK
3VID
3VNT
3VO3
3WZD
3WZE
4AG8
4AGC
4AGD
4ASD
4ASE
5EW3
5OYJ
6GQO
6GQP
6GQQ
3CKI
Enriched GO Terms of Interacting Partners
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