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KDR and DNM2
Number of citations of the paper that reports this interaction (PubMedID
16049137
)
31
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
KDR
DNM2
Description
kinase insert domain receptor
dynamin 2
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Endosome
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Junction
Receptor Complex
Membrane Raft
Sorting Endosome
Golgi Membrane
Phagocytic Cup
Photoreceptor Inner Segment
Cell
Nucleus
Cytoplasm
Endosome
Golgi Apparatus
Trans-Golgi Network
Centrosome
Cytosol
Microtubule
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Postsynaptic Density
Microtubule Cytoskeleton
Membrane
Lamellipodium
Axon
Growth Cone
Midbody
Endocytic Vesicle Membrane
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Mitochondrial Membrane
Ruffle Membrane
Protein-containing Complex
Dendritic Spine
Dendritic Spine Head
Synapse
Postsynaptic Membrane
Clathrin-coated Endocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Presynapse
Postsynaptic Endocytic Zone Membrane
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor-activated Receptor Activity
Integrin Binding
Protein Binding
ATP Binding
Growth Factor Binding
Vascular Endothelial Growth Factor Binding
Identical Protein Binding
Cadherin Binding
Hsp90 Protein Binding
GTPase Activity
Protein Binding
GTP Binding
Microtubule Binding
SH3 Domain Binding
Enzyme Binding
Protein Kinase Binding
D2 Dopamine Receptor Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Protein-containing Complex Binding
WW Domain Binding
Nitric-oxide Synthase Binding
Biological Process
Angiogenesis
Vasculogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Sprouting Angiogenesis
Cell Migration Involved In Sprouting Angiogenesis
Endothelium Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Positive Regulation Of Cell Proliferation
Regulation Of Cell Shape
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Positive Regulation Of Macroautophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Kinase Activity
Embryonic Hemopoiesis
Calcium-mediated Signaling Using Intracellular Calcium Source
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Endothelial Cell Differentiation
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Mitochondrial Depolarization
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Mitochondrial Fission
Cellular Response To Hydrogen Sulfide
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Vasculogenesis
G2/M Transition Of Mitotic Cell Cycle
Mitochondrial Fission
G Protein-coupled Receptor Internalization
Ventricular Septum Development
Regulation Of Transcription, DNA-templated
Golgi To Plasma Membrane Transport
Endocytosis
Receptor-mediated Endocytosis
Phagocytosis
Signal Transduction
Spermatogenesis
Response To Light Stimulus
Positive Regulation Of Lamellipodium Assembly
Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Axon Extension
Receptor Internalization
Transferrin Transport
Regulation Of Rac Protein Signal Transduction
Aorta Development
Response To Cocaine
Positive Regulation Of Apoptotic Process
Macropinocytosis
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Organelle Fission
Synaptic Vesicle Transport
Neuron Projection Morphogenesis
Positive Regulation Of Phagocytosis
Regulation Of Synapse Structure Or Activity
Regulation Of Nitric-oxide Synthase Activity
Coronary Vasculature Development
Membrane Organization
Membrane Fusion
Cellular Response To Carbon Monoxide
Cellular Response To X-ray
Cellular Response To Nitric Oxide
Postsynaptic Neurotransmitter Receptor Internalization
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Non-motile Cilium Assembly
Cellular Response To Dopamine
Regulation Of Golgi Organization
Positive Regulation Of Sodium:potassium-exchanging ATPase Activity
Negative Regulation Of Membrane Tubulation
Positive Regulation Of Clathrin-dependent Endocytosis
Pathways
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Toll Like Receptor 4 (TLR4) Cascade
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
NOSTRIN mediated eNOS trafficking
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Recycling pathway of L1
Clathrin-mediated endocytosis
NGF-stimulated transcription
Drugs
Sorafenib
Sunitinib
N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA
Cediranib
Vatalanib
XL999
TG-100801
XL820
CYC116
Ramucirumab
ABT-869
IMC-1C11
Semaxanib
Pazopanib
Midostaurin
Axitinib
4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Foretinib
Diseases
Centronuclear myopathy
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Endometriosis (
28537267
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
)
Lung function (FVC) (
30804560
)
Mosquito bite size (
28199695
)
Peak expiratory flow (
30804560
)
Serum VEGFR2 concentration (
25411163
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Bipolar disorder (
31043756
)
Height (
25429064
)
LDL cholesterol (
21347282
)
Interacting Genes
61 interacting genes:
ACP1
AIMP2
ANXA5
ATR
BMX
BTRC
CAV1
CBL
CCDC88A
CDH5
COL18A1
CRK
CSF2RB
CSNK1D
CTNNB1
DNM2
DUSP19
FBXO25
FBXW11
FLT1
FLT4
FRS2
FYN
GABARAP
GNA11
GNAQ
GRB10
GRB2
HSP90AA1
ILKAP
IQGAP1
ITGB3
MAPK1
NCK1
NRP1
P2RY2
PDCL3
PLCG1
PLCG2
PPM1A
PPM1B
PTPN11
PTPN12
PTPN6
PTPRR
RASA1
SERPINF1
SH2D2A
SHB
SHC1
SHC2
SRC
SRP72
STAT1
STYX
SYNGAP1
TIMP3
VEGFA
VEGFC
VEGFD
YES1
57 interacting genes:
AMPH
AOC1
AP2A1
APP
ATF7IP
ATXN3
BIN1
CCDC90B
CCR5
CCT7
CDK1
CTTN
DDX39B
DNM1
DNMT1
DYNC1I1
DYNLL1
EIF3L
EPS15
FNBP1L
GDF9
GOLGA2
GRAP2
GRB2
HCK
HMGB1
ITSN1
ITSN2
KDR
MAN1B1
MANEA
MPHOSPH6
MPP6
NTAQ1
PDE6G
PFN1
PPIB
PSTPIP1
PTK2
RHOU
RPS2
RWDD2B
SH3GL2
SH3GLB1
SHANK1
SHANK2
SNX9
SPRY2
SRC
TIAM2
TRIP10
TYK2
VAV1
WBP4
XIAP
ZBTB16
ZFAND6
Entrez ID
3791
1785
HPRD ID
01867
03852
Ensembl ID
ENSG00000128052
ENSG00000079805
Uniprot IDs
P35968
P50570
Q8N1K8
PDB IDs
1VR2
1Y6A
1Y6B
1YWN
2M59
2MET
2MEU
2OH4
2P2H
2P2I
2QU5
2QU6
2RL5
2X1W
2X1X
2XIR
3B8Q
3B8R
3BE2
3C7Q
3CJF
3CJG
3CP9
3CPB
3CPC
3DTW
3EFL
3EWH
3KVQ
3S35
3S36
3S37
3U6J
3V2A
3V6B
3VHE
3VHK
3VID
3VNT
3VO3
3WZD
3WZE
4AG8
4AGC
4AGD
4ASD
4ASE
5EW3
5OYJ
6GQO
6GQP
6GQQ
2YS1
Enriched GO Terms of Interacting Partners
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