ITK and BLNK

Number of citations of the paper that reports this interaction (PubMedID 10556826)
63

Data Source:
HPRD (in vitro)

		ITK	BLNK
Description		IL2 inducible T cell kinase	B cell linker
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cell-cell Junction	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Interferon-gamma Production Interleukin-4 Production Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction
Pathways		Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Staurosporine Pazopanib
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Daytime sleep phenotypes ( 27126917) Heel bone mineral density ( 30598549) Personality traits in bipolar disorder ( 21368711)
Interacting Genes		31 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 FASLG FGFR1 FYN GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS	20 interacting genes: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1
Entrez ID		3702	29760
HPRD ID		01746	05153
Ensembl ID		ENSG00000113263	ENSG00000095585
Uniprot IDs		Q08881	Q2MD54 Q2MD59 Q8WV28
PDB IDs		1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?