ITK and FGFR1

Number of citations of the paper that reports this interaction (PubMedID 22974441)
10

Data Source:
BioGRID (unspecified method)

		ITK	FGFR1
Description		IL2 inducible T cell kinase	fibroblast growth factor receptor 1
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GO Annotations	Cellular Component	Nucleus Cytosol Cell-cell Junction	Extracellular Region Nucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Receptor Complex
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Receptor-receptor Interaction
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Interferon-gamma Production Interleukin-4 Production Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Skeletal System Development Angiogenesis Ureteric Bud Development In Utero Embryonic Development Organ Induction Neuron Migration Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Phosphate Transport Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Ventricular Zone Neuroblast Division Embryonic Limb Morphogenesis Midbrain Development Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Inner Ear Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Paraxial Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Cell Maturation Skeletal System Morphogenesis Mesenchymal Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Auditory Receptor Cell Development Branching Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Vitamin D3 Metabolic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Parathyroid Hormone Secretion Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Signaling by activated point mutants of FGFR1 Signaling by FGFR1 in disease Signaling by plasma membrane FGFR1 fusions
Drugs		Staurosporine Pazopanib	Palifermin Sorafenib Heparin SU4984 XL999 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE Regorafenib Ponatinib Lenvatinib Nintedanib
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Hypogonadotropic hypogonadism; Kallmann syndrome (KAL) Osteoglophonic dysplasia (OD); Osteoglophonic dwarfism (OGD) Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Daytime sleep phenotypes ( 27126917) Heel bone mineral density ( 30598549) Personality traits in bipolar disorder ( 21368711)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Birth weight ( 31043758) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Nonsyndromic cleft lip with cleft palate ( 28232668) PR interval ( 30046033) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Schizophrenia ( 29483656)
Interacting Genes		31 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 FASLG FGFR1 FYN GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS	64 interacting genes: BNIP2 CDH1 CREBBP CRK CTPS2 EPHA4 ERBB2 ERBB3 FBXO7 FDPS FGF1 FGF10 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 HTR1A IL17RD ITGB3 ITK KLB KPNB1 L1CAM MFHAS1 MMP2 NCAM1 NCK1 NCK2 NECTIN1 NEDD4 NRP1 PDGFRB PDK1 PDP1 PIK3R1 PIK3R2 PLCG1 PTK6 PTPN1 RARA RASA1 RPS6KA1 RPS6KA3 RTN1 RTN3 SH3BP2 SHC1 SLA SOS1 TNK2 TNS2 VAV1 YES1
Entrez ID		3702	2260
HPRD ID		01746	00634
Ensembl ID		ENSG00000113263	ENSG00000077782
Uniprot IDs		Q08881	A0A0S2Z3Q6 A0A3B3ISD1 P11362
PDB IDs		1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM	1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65 4NK9 4NKA 4NKS 4RWI 4RWJ 4RWK 4RWL 4UWB 4UWC 4UWY 4V01 4V04 4V05 4WUN 4ZSA 5A46 5A4C 5AM6 5AM7 5B7V 5EW8 5FLF 5O49 5O4A 5UQ0 5UR1 5VND 5W21 5W59 5Z0S 5ZV2 6C18 6C19 6C1B 6C1C 6C1O 6ITJ 6MZQ 6MZW 6NVL 6P68 6P69
Enriched GO Terms of Interacting Partners?
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