INHBB and ACVR2A

Number of citations of the paper that reports this interaction (PubMedID 11266516)
11

Data Source:
HPRD (in vivo)

		INHBB	ACVR2A
Description		inhibin subunit beta B	activin A receptor type 2A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm Cell Periphery	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Activin-activated Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Protein Self-association Metal Ion Binding Activin Binding BMP Receptor Activity
	Biological Process	Ovarian Follicle Development Defense Response Cellular Response To Starvation Response To Wounding Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Cellular Response To Leptin Stimulus Adhesion Of Symbiont To Host Cell Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Hepatocyte Growth Factor Biosynthetic Process Oocyte Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway	Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Mesoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Sperm Ejaculation Penile Erection Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Regulation Of Nitric-oxide Synthase Activity Sertoli Cell Proliferation Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus
Pathways		Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs			Sotatercept
Diseases
GWAS		Age-related macular degeneration ( 23326517) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 22747683 27182965) Obesity ( 21552555) Urate levels ( 23263486)	Adventurousness ( 30643258) Arterial stiffness index ( 31235810) Asthma (adult onset) ( 31036433) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Cerebrospinal T-tau levels ( 28247064) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Feeling tense ( 29500382) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Loneliness (MTAG) ( 29970889) Neutrophil percentage of granulocytes ( 27863252) Photic sneeze reflex ( 30899065) Response to statin therapy ( 20339536) Urate levels ( 23263486) White blood cell count (basophil) ( 27863252)
Interacting Genes		12 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B BMPR2 FNTA IGSF1 INHA INHBA INHBC TDGF1	23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 DAXX ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TCTEX1D4 TDGF1 TGFBR3
Entrez ID		3625	92
HPRD ID		00934	00025
Ensembl ID		ENSG00000163083	ENSG00000121989
Uniprot IDs		P09529	P27037
PDB IDs			3Q4T 3SOC 4ASX 5NH3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?