ACVR2A and ENG

Number of citations of the paper that reports this interaction (PubMedID 9872992)
133

Data Source:
HPRD (in vivo)

		ACVR2A	ENG
Description		activin A receptor type 2A	endoglin
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Integral Component Of Membrane Nuclear Body Receptor Complex Endothelial Microparticle
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Activin-activated Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Protein Self-association Metal Ion Binding Activin Binding BMP Receptor Activity	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Mesoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Sperm Ejaculation Penile Erection Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Regulation Of Nitric-oxide Synthase Activity Sertoli Cell Proliferation Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus	Chronological Cell Aging Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Positive Regulation Of Protein Phosphorylation Heart Looping Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Cell Adhesion Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Autophosphorylation Response To Corticosteroid Positive Regulation Of Collagen Biosynthetic Process Dorsal Aorta Morphogenesis Response To Drug Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Protein Kinase B Signaling Atrial Cardiac Muscle Tissue Morphogenesis Bone Development Extracellular Matrix Constituent Secretion Cellular Response To Mechanical Stimulus Response To Transforming Growth Factor Beta Endocardial Cushion To Mesenchymal Transition Vascular Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs		Sotatercept
Diseases			Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Adventurousness ( 30643258) Arterial stiffness index ( 31235810) Asthma (adult onset) ( 31036433) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Cerebrospinal T-tau levels ( 28247064) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Feeling tense ( 29500382) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Loneliness (MTAG) ( 29970889) Neutrophil percentage of granulocytes ( 27863252) Photic sneeze reflex ( 30899065) Response to statin therapy ( 20339536) Urate levels ( 23263486) White blood cell count (basophil) ( 27863252)	Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148)
Interacting Genes		23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 DAXX ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TCTEX1D4 TDGF1 TGFBR3	14 interacting genes: ACVR1 ACVR2A BMP2 BMP7 CNTRL GDF2 INHBA TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3
Entrez ID		92	2022
HPRD ID		00025	00565
Ensembl ID		ENSG00000121989	ENSG00000106991
Uniprot IDs		P27037	A0A024R878 B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0
PDB IDs		3Q4T 3SOC 4ASX 5NH3	5HZV 5HZW 5I04
Enriched GO Terms of Interacting Partners?
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