IL18 and IL18RAP

Number of citations of the paper that reports this interaction (PubMedID 9792649)
61

Data Source:
HPRD (in vivo)

		IL18	IL18RAP
Description		interleukin 18	interleukin 18 receptor accessory protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Plasma Membrane Interleukin-18 Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Interleukin-18 Receptor Binding	Interleukin-18 Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	MAPK Cascade Angiogenesis Inflammatory Response Cell-cell Signaling Cell Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase B Activity Interleukin-6 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Cytokine Production Chemokine Biosynthetic Process T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-2 Biosynthetic Process Interferon-gamma Biosynthetic Process Positive Regulation Of Activated T Cell Proliferation Neutrophil Activation Interleukin-13 Biosynthetic Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Triglyceride Homeostasis Cellular Response To Organic Cyclic Compound Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production	Inflammatory Response Immune Response Cell Proliferation Interferon-gamma Production Interleukin-6 Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Cytokine Production Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide
Pathways		Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection	Interleukin-18 signaling
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Protein quantitative trait loci ( 18464913)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Blood protein levels ( 30072576 28240269) Celiac disease ( 22057235 20190752 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lymphocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Systemic lupus erythematosus ( 28714469)
Interacting Genes		8 interacting genes: CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2	3 interacting genes: APP CD48 IL18
Entrez ID		3606	8807
HPRD ID		02976	05147
Ensembl ID		ENSG00000150782	ENSG00000115607
Uniprot IDs		A0A024R3E0 Q14116	O95256
PDB IDs		1J0S 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU	3WO4
Enriched GO Terms of Interacting Partners?
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