IL3RA and CSF2RB

Number of citations of the paper that reports this interaction (PubMedID 8649415)
12

Data Source:
HPRD (in vitro)

		IL3RA	CSF2RB
Description		interleukin 3 receptor subunit alpha	colony stimulating factor 2 receptor subunit beta
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Cytokine Binding	Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	MAPK Cascade Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	MAPK Cascade Signal Transduction Respiratory Gaseous Exchange Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Cellular Protein Metabolic Process
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Interleukin receptor SHC signaling
Drugs		Sargramostim	Sargramostim NPI 32101 Resatorvid
Diseases
GWAS		Schizophrenia ( 17522711)	Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)
Interacting Genes		15 interacting genes: CDC25A CDK1 CISH CSF2 CSF2RB FOXP1 GNA12 IL3 JAK1 JAK2 LNX1 NR0B2 PPP1CC SAE1 SGK2	27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ
Entrez ID		3563	1439
HPRD ID		02392	00739
Ensembl ID		ENSG00000185291	ENSG00000100368
Uniprot IDs		P26951	P32927 Q6NSJ8
PDB IDs		4JZJ 5UV8 5UWC	1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU
Enriched GO Terms of Interacting Partners?
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