IGHG1 and FCGR3A

Number of citations of the paper that reports this interaction (PubMedID 15037082)
81

Data Source:
HPRD (in vitro)

		IGHG1	FCGR3A
Description		immunoglobulin heavy constant gamma 1 (G1m marker)	Fc fragment of IgG receptor IIIa
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Blood Microparticle	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Antigen Binding Protein Binding Immunoglobulin Receptor Binding	IgG Binding
	Biological Process	Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation Complement Activation, Classical Pathway Cytokine-mediated Signaling Pathway Regulation Of Complement Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Defense Response To Bacterium Innate Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation	Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Sarilumab Benralizumab
Diseases			NK cell defects, including the following disease: CD16 deficiency Systemic lupus erythematosus
GWAS		Blood protein levels ( 29875488) Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)	Birth weight ( 31043758) Blood protein levels ( 28240269) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Inflammatory bowel disease ( 28067908 23128233) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 30498034 23830517) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: CD40LG FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5	18 interacting genes: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25
Entrez ID		3500	2214
HPRD ID		11755	00903
Ensembl ID		ENSG00000211896	ENSG00000203747
Uniprot IDs			M9MML0 P08637
PDB IDs			3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5
Enriched GO Terms of Interacting Partners?
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