FCGR3A and ZBTB25

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FCGR3A	ZBTB25
Description		Fc fragment of IgG receptor IIIa	zinc finger and BTB domain containing 25
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Nucleoplasm Cytoplasm
	Molecular Function	IgG Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response	Regulation Of Transcription, DNA-templated Gene Expression
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Sarilumab Benralizumab
Diseases		NK cell defects, including the following disease: CD16 deficiency Systemic lupus erythematosus
GWAS		Birth weight ( 31043758) Blood protein levels ( 28240269) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Inflammatory bowel disease ( 28067908 23128233) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 30498034 23830517) Ulcerative colitis ( 28067908)	Heel bone mineral density ( 30598549) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252)
Interacting Genes		18 interacting genes: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25	22 interacting genes: APIP COIL CYP2J2 DDIT3 FCGR3A FHL2 HCLS1 KCTD1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 SUMO2 TNIP1 TRAF2 TSSK3 ZBTB1
Entrez ID		2214	7597
HPRD ID		00903	01926
Ensembl ID		ENSG00000203747	ENSG00000089775
Uniprot IDs		M9MML0 P08637	G3V2K3 P24278
PDB IDs		3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5
Enriched GO Terms of Interacting Partners?
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