IGFBP6 and TF

Number of citations of the paper that reports this interaction (PubMedID 11297622)
26

Data Source:
HPRD (in vitro)

		IGFBP6	TF
Description		insulin like growth factor binding protein 6	transferrin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex	Extracellular Region Extracellular Space Cell Early Endosome Late Endosome Endoplasmic Reticulum Lumen Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of External Side Of Plasma Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Protein Binding Ferrous Iron Binding Ferric Iron Binding Ferric Iron Transmembrane Transporter Activity Iron Chaperone Activity Transferrin Receptor Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway	Retina Homeostasis Platelet Degranulation Cellular Iron Ion Homeostasis Actin Filament Organization Activation Of JUN Kinase Activity Response To Bacterium Osteoclast Differentiation Regulation Of Protein Stability Transferrin Transport Iron Ion Transmembrane Transport Regulation Of Iron Ion Transport Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor-mediated Endocytosis Iron Ion Homeostasis SMAD Protein Signal Transduction Membrane Organization ERK1 And ERK2 Cascade Cellular Response To Iron Ion Trivalent Inorganic Cation Transport Positive Regulation Of Cell Motility
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling
Drugs			Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Chromium
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Alcohol consumption (transferrin glycosylation) ( 21665994) Blood protein levels ( 30072576) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 25224454 21483845 21208937 19084217) Iron status biomarkers (iron levels) ( 28334935 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 25352340) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Red cell distribution width ( 27863252)
Interacting Genes		5 interacting genes: DDX10 IGF1 IGF2 TF UBQLN4	20 interacting genes: CALR CANX CUBN GRB2 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 SH3BP2 SMAD3 TFR2 TFRC TIMELESS TUBB3 VKORC1
Entrez ID		3489	7018
HPRD ID		00902	01811
Ensembl ID		ENSG00000167779	ENSG00000091513
Uniprot IDs		P24592	A0PJA6 P02787 Q06AH7
PDB IDs		1RMJ	1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6SOY 6SOZ
Enriched GO Terms of Interacting Partners?
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