TF and TFR2

Number of citations of the paper that reports this interaction (PubMedID 11027676)
49

Data Source:
HPRD (in vitro, in vivo)

		TF	TFR2
Description		transferrin	transferrin receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Early Endosome Late Endosome Endoplasmic Reticulum Lumen Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of External Side Of Plasma Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex	Cell Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Protein Binding Ferrous Iron Binding Ferric Iron Binding Ferric Iron Transmembrane Transporter Activity Iron Chaperone Activity Transferrin Receptor Binding	Transferrin Receptor Activity Protein Binding Co-receptor Binding
	Biological Process	Retina Homeostasis Platelet Degranulation Cellular Iron Ion Homeostasis Actin Filament Organization Activation Of JUN Kinase Activity Response To Bacterium Osteoclast Differentiation Regulation Of Protein Stability Transferrin Transport Iron Ion Transmembrane Transport Regulation Of Iron Ion Transport Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor-mediated Endocytosis Iron Ion Homeostasis SMAD Protein Signal Transduction Membrane Organization ERK1 And ERK2 Cascade Cellular Response To Iron Ion Trivalent Inorganic Cation Transport Positive Regulation Of Cell Motility	Iron Ion Transport Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Acute-phase Response Response To Iron Ion Transferrin Transport Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Protein Maturation
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling	Transferrin endocytosis and recycling
Drugs		Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Chromium
Diseases			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Blood protein levels ( 30072576) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 25224454 21483845 21208937 19084217) Iron status biomarkers (iron levels) ( 28334935 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 25352340) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Red cell distribution width ( 27863252)	Hematocrit ( 27863252 28017375 19862010) Hematological parameters ( 19820697) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Iron status biomarkers ( 21208937) Iron status biomarkers (iron levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340) Mean corpuscular hemoglobin ( 29403010 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 27863252 28017375 19862010) Platelet count ( 27863252) Plateletcrit ( 27863252) Red blood cell count ( 29403010 28453575 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		20 interacting genes: CALR CANX CUBN GRB2 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 SH3BP2 SMAD3 TFR2 TFRC TIMELESS TUBB3 VKORC1	4 interacting genes: HFE PRKAR2B SOCS3 TF
Entrez ID		7018	7036
HPRD ID		01811	05282
Ensembl ID		ENSG00000091513	ENSG00000106327
Uniprot IDs		A0PJA6 P02787 Q06AH7	Q9UP52
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6SOY 6SOZ
Enriched GO Terms of Interacting Partners?
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