IFNAR1 and BRCC3

Number of citations of the paper that reports this interaction (PubMedID 24075985)
25

Data Source:
BioGRID (enzymatic study)

		IFNAR1	BRCC3
Description		interferon alpha and beta receptor subunit 1	BRCA1/BRCA2-containing complex subunit 3
Image
GO Annotations	Cellular Component	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex
	Molecular Function	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding Lys63-specific Deubiquitinase Activity
	Biological Process	JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Response To X-ray Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cell Division Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant Natural alpha interferon omega interferon	Zinc
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)	Venous thromboembolism ( 31676865)
Interacting Genes		24 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70	9 interacting genes: BRCA1 FANCG IFNAR1 NUMA1 SNAPC5 SUMO2 UBC UBE2D1 UIMC1
Entrez ID		3454	79184
HPRD ID		00126	06465
Ensembl ID		ENSG00000142166	ENSG00000185515
Uniprot IDs		A0A494C0E2 P17181	P46736
PDB IDs		3S98 3SE3 3SE4 4PO6	6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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