IFIT1 and EIF3E

Number of citations of the paper that reports this interaction (PubMedID 11118224)
85

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		IFIT1	EIF3E
Description		interferon induced protein with tetratricopeptide repeats 1	eukaryotic translation initiation factor 3 subunit E
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GO Annotations	Cellular Component	Cytoplasm Cytosol Host Cell	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3e
	Molecular Function	RNA Binding Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Cadherin Binding Protein N-terminus Binding
	Biological Process	Response To Virus Viral Process Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Regulation Of Defense Response To Virus Negative Regulation Of Helicase Activity Defense Response To Virus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Exogenous DsRNA	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Positive Regulation Of MRNA Binding
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Coffee consumption ( 31046077) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		4 interacting genes: EIF3E IFIT2 IFIT3 IFIT5	25 interacting genes: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 GPAA1 GPBP1L1 HAP1 IFIT1 MAPK1IP1L NDRG1 NSF PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63
Entrez ID		3434	3646
HPRD ID		00983	03734
Ensembl ID		ENSG00000185745	ENSG00000104408
Uniprot IDs		P09914	P60228
PDB IDs		4HOU 5UDI 5UDJ 5UDK 5UDL 5W5H 5W5I 6C6K	3J8B 3J8C 6FEC
Enriched GO Terms of Interacting Partners?
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