PRMT1 and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 9029147)
33

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro, in vivo)

		PRMT1	IFNAR1
Description		protein arginine methyltransferase 1	interferon alpha and beta receptor subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H4-R3 Specific) Mitogen-activated Protein Kinase P38 Binding S-adenosyl-L-methionine Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding
	Biological Process	In Utero Embryonic Development Protein Methylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Neuron Projection Development Histone H4-R3 Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hemoglobin Biosynthetic Process Protein Homooligomerization Positive Regulation Of P38MAPK Cascade	JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway
Pathways		RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling
Drugs		S-adenosyl-L-homocysteine	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant Natural alpha interferon omega interferon
Diseases
GWAS		Schizophrenia ( 29483656)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		100 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EIF4A1 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GPATCH2L GRHL3 GRIP1 H3C1 H4-16 H4C14 HABP4 HNF4A HNRNPA1 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 IMPDH2 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MBP MECOM MED31 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PPARA PRMT8 QKI RBM15 RELA RNF187 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 STAT1 STAT5A STUB1 SUPT5H SYNCRIP TBX6 TERF2 THRB TP53 TRIM48 UBAP2L UBE4B VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZMYM5 ZNF451	24 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		3276	3454
HPRD ID		04257	00126
Ensembl ID		ENSG00000126457	ENSG00000142166
Uniprot IDs		Q99873	A0A494C0E2 P17181
PDB IDs		6NT2	3S98 3SE3 3SE4 4PO6
Enriched GO Terms of Interacting Partners?
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