HOXC4 and SOX10

Number of citations of the paper that reports this interaction (PubMedID 16582099)
57

Data Source:
HPRD (two hybrid)

		HOXC4	SOX10
Description		homeobox C4	SRY-box transcription factor 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm Extrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Activating Transcription Factor Binding HMG Box Domain Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Skeletal System Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Melanocyte Differentiation Positive Regulation Of Myelination Lacrimal Gland Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Waardenburg syndrome (WS)
GWAS		Diastolic blood pressure ( 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878 27618447 30578418) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		13 interacting genes: APP ELMOD2 HTT NCK2 NSD3 PRKDC PRMT5 PRMT6 RCHY1 RNF32 SOX10 SUV39H1 XRCC6	29 interacting genes: ALX4 CDK6 CEBPA DLX5 EGR2 EXOC5 GSK3B HHEX HIVEP1 HOXA3 HOXC4 JUN MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1
Entrez ID		3221	6663
HPRD ID		00860	03752
Ensembl ID		ENSG00000198353	ENSG00000100146
Uniprot IDs		A0A024RB51 P09017 Q86TF7	A0A024R1N6 P56693
PDB IDs
Enriched GO Terms of Interacting Partners?
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