HLA-DRB1 and TRIM21

Number of citations of the paper that reports this interaction (PubMedID 18022694)
13

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		HLA-DRB1	TRIM21
Description		major histocompatibility complex, class II, DR beta 1	tripartite motif containing 21
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex
	Molecular Function	MHC Class II Protein Complex Binding Polysaccharide Binding Peptide Antigen Binding	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Interferon-gamma Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Type I diabetes mellitus Dilated cardiomyopathy (DCM) Tuberculosis Asthma Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis
GWAS		Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Antisaccade task score ( 31596458) Arterial stiffness index ( 31235810) Arthritis (juvenile idiopathic) ( 18576341) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Asthma ( 30929738 31619474 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Cervical cancer ( 23482656 28806749) Childhood ear infection ( 28928442) Childhood onset ulcerative colitis ( 29562276) Childhood steroid-sensitive nephrotic syndrome ( 29903748) Chronic lymphocytic leukemia ( 26956414) Cold sores ( 28928442) Creatinine levels ( 29403010) Crohn's disease ( 23850713 26891255 23266558) Drug-induced liver injury (flucloxacillin) ( 30661239) Enteric fever ( 25383971) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Estimated glomerular filtration rate ( 30604766) Family history of Alzheimer's disease ( 30617256) Giant cell arteritis ( 28041642 25817017) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Heart rate response to exercise ( 29769521) Hepatitis B vaccine response ( 24282030) Hepatocellular carcinoma ( 22807686) High density lipoprotein cholesterol levels ( 29403010) Hypothyroidism ( 22493691) IgA nephropathy ( 26028593 25305756 22197929) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 28067908) Joint damage in rheumatoid arthritis ( 31596875) Lapatinib-induced hepatotoxicity ( 25987243) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Lumiracoxib-related liver injury ( 20639878) Lung adenocarcinoma ( 28604730) Lymphocyte counts ( 29403010) Lymphoma ( 23349640) Medication use (immunosuppressants) ( 31015401) Metabolic syndrome ( 31589552) Mixed cellularity Hodgkin lymphoma ( 29196614) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Multiple sclerosis ( 22190364 19525953 19525955 18941528 27386562) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nephropathy ( 21399633) Neurofibrillary tangles ( 25188341) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Nodular sclerosis Hodgkin lymphoma ( 22086417 29196614) Oligoclonal band status in multiple sclerosis ( 25616667) Parental lifespan ( 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Pemphigus vulgaris ( 29857070) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cholangitis ( 28062665) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Reticulocyte count ( 27863252) Rheumatoid arthritis ( 25014791 21452313 17804836 30423114 18794853 17554300 24390342 20453841 20453842 28118524) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Scarlet fever ( 28928442) Schizophrenia ( 23212062) Serum IgE levels ( 25488688) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097066 28076899) Skin and soft tissue Staphylococcus aureus infection ( 26450422) Small cell lung carcinoma ( 28604730) Staphylococcus aureus infection ( 26450422) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 23273568 19838193 19838195) Systemic sclerosis ( 30247649 21779181) Takayasu arteritis ( 25604533 23830517) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Tuberculosis ( 29036319 28928442) Type 1 diabetes ( 17632545) Ulcerative colitis ( 28067908 23128233 21297633 19122664 23511034) Ulcerative colitis or Crohn's disease ( 21699788) Vitiligo ( 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Yeast infection ( 28928442)	Lung cancer ( 28604730)
Interacting Genes		9 interacting genes: CTAG1B HLA-DMA HLA-DRA MAGEA3 MARCHF1 TRA TRB TRIM21 ZDHHC17	52 interacting genes: APC CALR CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GABARAP GABARAPL1 GABARAPL2 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NIF3L1 PFKP RBCK1 RNF111 RO60 SKP2 SQSTM1 TBK1 TRIM27 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2H UBE2I UBE2L3 UBE2N UBE2V2 UBE2W USP15 USP2 USP4 YWHAZ
Entrez ID		3123	6737
HPRD ID		08349	00170
Ensembl ID		ENSG00000196126	ENSG00000132109
Uniprot IDs		A0A224MM52 D7RIH8 P01911 Q5Y7D1 X5DNQ0	P19474
PDB IDs		1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FYT 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2SEB 2WBJ 2XN9 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6HBY	2IWG 5JPX 5OLM 6FGA 6S53
Enriched GO Terms of Interacting Partners?
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