HLA-DRA and MBP

Number of citations of the paper that reports this interaction (PubMedID 9782128)
71

Data Source:
HPRD (in vitro)

		HLA-DRA	MBP
Description		major histocompatibility complex, class II, DR alpha	myelin basic protein
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Nucleus Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Polysaccharide Binding MHC Class II Receptor Activity Peptide Antigen Binding	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath
	Biological Process	Adaptive Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Cognition Interferon-gamma-mediated Signaling Pathway	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Permeability Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Interleukin-6 Secretion
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Acute-on-chronic liver failure in hepatitis B ( 28130311) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Antinuclear antibody levels ( 25186300) Asthma ( 23028483 21804548 30929738 31619474 29273806) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body mass index ( 28892062) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cardiometabolic and hematological traits ( 27668658) Chloride levels ( 29403010) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 23850713) Cystic fibrosis severity ( 21602797) Endometriosis ( 28881265) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262) Estimated glomerular filtration rate in diabetes ( 31451708) Feeling worry ( 29500382) Fibrinogen levels ( 28107422) Food antigen IgG levels ( 24962563) Frontotemporal dementia ( 24943344) Giant cell arteritis ( 28041642) Hepatitis B ( 28928442) Hepatitis B vaccine response ( 24282030) HIV-1 viral setpoint ( 26039976) Hodgkin's lymphoma ( 21037568 22286212) Inflammatory bowel disease ( 28008999 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung disease severity in cystic fibrosis ( 26417704) Lymphoma ( 23349640) Multiple sclerosis ( 17660530) Multiple sclerosis (OCB status) ( 23472185) Nodular sclerosis Hodgkin lymphoma ( 29196614) Non-obstructive azoospermia ( 22541561) Obstetric antiphospholipid syndrome ( 28424481) Parkinson's disease ( 20711177) Perceived unattractiveness to mosquitoes ( 28199695) Primary biliary cholangitis ( 28425483 28062665) Primary central nervous system lymphoma ( 31102405) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Sarcoidosis (non-Lofgren's syndrome) ( 26651848) SjÃ¶gren's syndrome ( 24097066 24097067) Staphylococcus aureus infection ( 26450422) Systemic juvenile idiopathic arthritis ( 27927641) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Tuberculosis ( 29036319) Ulcerative colitis ( 28008999 24837172 28067908 23128233 20228798 18836448 21297633 19122664) Urate levels ( 31578528) Vitiligo ( 20410501) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for body mass index ( 28552196) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)
Interacting Genes		11 interacting genes: CD63 CD74 CD82 HLA-DMA HLA-DMB HLA-DRB1 HLA-DRB5 MARCHF1 MBP PRPF40B TLR3	72 interacting genes: ABL1 APTX ATN1 ATXN1 BMP2K CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTPRA RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		3122	4155
HPRD ID		00833	01158
Ensembl ID		ENSG00000204287	ENSG00000197971
Uniprot IDs		A0A0G2JMH6 P01903	A0A024R384 P02686
PDB IDs		1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HQR 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2Q6W 2SEB 2WBJ 2XN9 3C5J 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4H1L 4H25 4H26 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 5V4M 5V4N 6ATF 6ATI 6ATZ 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR	1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?
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