HLA-DPA1 and CD4

Number of citations of the paper that reports this interaction (PubMedID 12899833)
73

Data Source:
HPRD (in vivo)

		HLA-DPA1	CD4
Description		major histocompatibility complex, class II, DP alpha 1	CD4 molecule
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Cell Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	MHC Class II Receptor Activity Peptide Antigen Binding	Virus Receptor Activity Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Coreceptor Activity Immunoglobulin Binding Enzyme Binding Protein Kinase Binding Signaling Receptor Activity Interleukin-16 Binding Interleukin-16 Receptor Activity MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Tyrosine Kinase Binding
	Biological Process	Adaptive Immune Response Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma	Cytokine Production Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Induction By Virus Of Host Cell-cell Fusion Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Fusion Of Virus Membrane With Host Plasma Membrane Cytokine-mediated Signaling Pathway T Cell Differentiation Macrophage Differentiation Response To Estradiol Maintenance Of Protein Location In Cell Response To Vitamin D Positive Regulation Of Kinase Activity Helper T Cell Enhancement Of Adaptive Immune Response Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Entry Into Host T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Monocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Entry Into Host Cell Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Calcium Ion Transport Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	Alpha-defensins Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Vpu mediated degradation of CD4 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Other interleukin signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Antithymocyte immunoglobulin (rabbit)
Diseases		Dilated cardiomyopathy (DCM)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Asthma ( 30929738 31619474) Asthma (childhood onset) ( 30929738) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 25802187) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hepatitis B ( 21750111) Hepatitis B (viral clearance) ( 22737229) IgA nephropathy ( 25305756) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mortality in sepsis ( 27639821) Myositis ( 26291516) Nephropathy ( 21399633) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 29534301) SjÃ¶gren's syndrome ( 24097066) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533)	Bone mineral density (hip) ( 30172743) Response to Vitamin E supplementation ( 22437554)
Interacting Genes		3 interacting genes: CD4 CD74 HLA-DPB1	38 interacting genes: ABCB1 ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCHF4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119
Entrez ID		3113	920
HPRD ID		00835	01740
Ensembl ID		ENSG00000231389	ENSG00000010610
Uniprot IDs		P20036 X5CKE2	A0A4Y5UGE4 B0AZV7 B4DT49 P01730
PDB IDs		3LQZ 4P4K 4P4R 4P57 4P5K 4P5M	1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3J70 3JCB 3JCC 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H 4RQS 5A7X 5A8H 5CAY 5THR 5U1F 5VN3 6CM3 6EDU 6MEO 6MET
Enriched GO Terms of Interacting Partners?
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