HLA-DPA1 and HLA-DPB1

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		HLA-DPA1	HLA-DPB1
Description		major histocompatibility complex, class II, DP alpha 1	major histocompatibility complex, class II, DP beta 1
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	MHC Class II Receptor Activity Peptide Antigen Binding	Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma	Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs
Diseases		Dilated cardiomyopathy (DCM)	Dilated cardiomyopathy (DCM)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Asthma ( 30929738 31619474) Asthma (childhood onset) ( 30929738) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 25802187) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hepatitis B ( 21750111) Hepatitis B (viral clearance) ( 22737229) IgA nephropathy ( 25305756) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mortality in sepsis ( 27639821) Myositis ( 26291516) Nephropathy ( 21399633) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 29534301) SjÃ¶gren's syndrome ( 24097066) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Anti-rubella virus IgG levels ( 30053915) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Chronic hepatitis B infection ( 24940741 25802187) Dermatomyositis ( 27153935) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Gait speed in old age ( 28077804) Hepatitis B ( 21750111 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) IgA nephropathy ( 25305756) Monocyte count ( 27863252) Myositis ( 26291516) Nephropathy ( 21399633) Nodular sclerosis Hodgkin lymphoma ( 29196614) Plantar warts ( 28928442) Primary biliary cholangitis ( 28425483) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 31243853 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Severe aplastic anemia ( 32004448) SjÃ¶gren's syndrome ( 24097066 28076899) Susceptibility to persistent hepatitis B virus infection ( 27244555) Systemic sclerosis ( 21779181) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Wegener's granulomatosis ( 23740775) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		3 interacting genes: CD4 CD74 HLA-DPB1	7 interacting genes: CD74 COPB1 HLA-DPA1 LZTS2 ROBO2 RTN4 TRIP6
Entrez ID		3113	3115
HPRD ID		00835	00832
Ensembl ID		ENSG00000231389	ENSG00000223865
Uniprot IDs		P20036 X5CKE2	I4EC15 P04440
PDB IDs		3LQZ 4P4K 4P4R 4P57 4P5K 4P5M	3LQZ 4P4K 4P4R 4P57 4P5K 4P5M
Enriched GO Terms of Interacting Partners?
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