HLA-DMA and HLA-DRB1

Number of citations of the paper that reports this interaction (PubMedID 11070170)
50

Data Source:
HPRD (in vitro)

		HLA-DMA	HLA-DRB1
Description		major histocompatibility complex, class II, DM alpha	major histocompatibility complex, class II, DR beta 1
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GO Annotations	Cellular Component	Lysosomal Membrane Cell Surface Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding	MHC Class II Protein Complex Binding Polysaccharide Binding Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways			Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs
Diseases		Allograft rejection	Type I diabetes mellitus Dilated cardiomyopathy (DCM) Tuberculosis Asthma Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)	Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Antisaccade task score ( 31596458) Arterial stiffness index ( 31235810) Arthritis (juvenile idiopathic) ( 18576341) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Asthma ( 30929738 31619474 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Cervical cancer ( 23482656 28806749) Childhood ear infection ( 28928442) Childhood onset ulcerative colitis ( 29562276) Childhood steroid-sensitive nephrotic syndrome ( 29903748) Chronic lymphocytic leukemia ( 26956414) Cold sores ( 28928442) Creatinine levels ( 29403010) Crohn's disease ( 23850713 26891255 23266558) Drug-induced liver injury (flucloxacillin) ( 30661239) Enteric fever ( 25383971) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Estimated glomerular filtration rate ( 30604766) Family history of Alzheimer's disease ( 30617256) Giant cell arteritis ( 28041642 25817017) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Heart rate response to exercise ( 29769521) Hepatitis B vaccine response ( 24282030) Hepatocellular carcinoma ( 22807686) High density lipoprotein cholesterol levels ( 29403010) Hypothyroidism ( 22493691) IgA nephropathy ( 26028593 25305756 22197929) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 28067908) Joint damage in rheumatoid arthritis ( 31596875) Lapatinib-induced hepatotoxicity ( 25987243) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Lumiracoxib-related liver injury ( 20639878) Lung adenocarcinoma ( 28604730) Lymphocyte counts ( 29403010) Lymphoma ( 23349640) Medication use (immunosuppressants) ( 31015401) Metabolic syndrome ( 31589552) Mixed cellularity Hodgkin lymphoma ( 29196614) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Multiple sclerosis ( 22190364 19525953 19525955 18941528 27386562) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nephropathy ( 21399633) Neurofibrillary tangles ( 25188341) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Nodular sclerosis Hodgkin lymphoma ( 22086417 29196614) Oligoclonal band status in multiple sclerosis ( 25616667) Parental lifespan ( 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Pemphigus vulgaris ( 29857070) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cholangitis ( 28062665) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Reticulocyte count ( 27863252) Rheumatoid arthritis ( 25014791 21452313 17804836 30423114 18794853 17554300 24390342 20453841 20453842 28118524) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Scarlet fever ( 28928442) Schizophrenia ( 23212062) Serum IgE levels ( 25488688) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097066 28076899) Skin and soft tissue Staphylococcus aureus infection ( 26450422) Small cell lung carcinoma ( 28604730) Staphylococcus aureus infection ( 26450422) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 23273568 19838193 19838195) Systemic sclerosis ( 30247649 21779181) Takayasu arteritis ( 25604533 23830517) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Tuberculosis ( 29036319 28928442) Type 1 diabetes ( 17632545) Ulcerative colitis ( 28067908 23128233 21297633 19122664 23511034) Ulcerative colitis or Crohn's disease ( 21699788) Vitiligo ( 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Yeast infection ( 28928442)
Interacting Genes		8 interacting genes: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2	9 interacting genes: CTAG1B HLA-DMA HLA-DRA MAGEA3 MARCHF1 TRA TRB TRIM21 ZDHHC17
Entrez ID		3108	3123
HPRD ID		00830	08349
Ensembl ID		ENSG00000204257	ENSG00000196126
Uniprot IDs		Q31604 Q6ICR9	A0A224MM52 D7RIH8 P01911 Q5Y7D1 X5DNQ0
PDB IDs		4I0P	1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FYT 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2SEB 2WBJ 2XN9 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6HBY
Enriched GO Terms of Interacting Partners?
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