ZNRD1 and ZNF593

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		ZNRD1	ZNF593
Description		zinc ribbon domain containing 1	zinc finger protein 593
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase I Complex	Nucleoplasm Nucleolus Preribosome, Large Subunit Precursor
	Molecular Function	Nucleic Acid Binding DNA-directed 5'-3' RNA Polymerase Activity Zinc Ion Binding	DNA Binding Protein Binding Zinc Ion Binding Ribosomal Large Subunit Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription MRNA Cleavage Positive Regulation Of Gene Expression, Epigenetic	Ribosomal Large Subunit Export From Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) HIV-1 control ( 20041166) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		17 interacting genes: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP MAPK8IP2 NONO SACS SERPINA3 TNS2 UBE2I ZNF593	8 interacting genes: GPR3 LNX1 MAP3K20 MAP3K7 MAPK8IP2 RAB1A SRPK2 ZNRD1
Entrez ID		30834	51042
HPRD ID		09601	15866
Ensembl ID		ENSG00000066379	ENSG00000142684
Uniprot IDs		Q2L6J2 Q9P1U0	O00488
PDB IDs			1ZR9
Enriched GO Terms of Interacting Partners?
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