KCNIP2 and KCND2

Number of citations of the paper that reports this interaction (PubMedID 11287421)
75

Data Source:
HPRD (in vitro)

		KCNIP2	KCND2
Description		potassium voltage-gated channel interacting protein 2	potassium voltage-gated channel subfamily D member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Potassium Channel Complex Synapse	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Postsynaptic Density Integral Component Of Membrane Cell Junction Dendrite Intrinsic Component Of Plasma Membrane Neuronal Cell Body Membrane Dendritic Spine Perikaryon Plasma Membrane Raft Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	A-type (transient Outward) Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding ER Retention Sequence Binding Protein N-terminus Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization	Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Protein Binding Metal Ion Binding Voltage-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Detection Of Calcium Ion Potassium Ion Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Regulation Of Heart Contraction Clustering Of Voltage-gated Potassium Channels Cardiac Conduction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Potassium Ion Export Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Voltage-gated Potassium Channel Activity	Action Potential Chemical Synaptic Transmission Neuronal Action Potential Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Locomotor Rhythm Protein Homooligomerization Regulation Of Postsynaptic Membrane Potential Cardiac Conduction Cellular Response To Hypoxia Potassium Ion Transmembrane Transport
Pathways		Phase 1 - inactivation of fast Na+ channels	Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels
Drugs			Disopyramide Amitriptyline Imipramine Dalfampridine
Diseases
GWAS			Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Alcohol and nicotine co-dependence ( 22488850) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		3 interacting genes: KCND2 KCND3 KCNIP1	8 interacting genes: DLG4 DPP10 FLNC IL16 KCNIP1 KCNIP2 KCNIP4 NCS1
Entrez ID		30819	3751
HPRD ID		06880	09254
Ensembl ID		ENSG00000120049	ENSG00000184408
Uniprot IDs		A0A2R8Y6D7 B3KSZ5 Q9NS61	A4D0V9 Q9NZV8
PDB IDs
Enriched GO Terms of Interacting Partners?
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