GZMK and PNKP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GZMK	PNKP
Description		granzyme K	polynucleotide kinase 3'-phosphatase
Image
GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	Proteolysis Positive Regulation Of Apoptotic Process Negative Regulation Of Oxidoreductase Activity	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleoside Monophosphate Phosphorylation Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Blood protein levels ( 30072576 29875488)
Interacting Genes		12 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TUBB3 UFD1 VCP	17 interacting genes: APP GZMK IKZF1 KDM1A KRTAP4-12 LMNA MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		3003	11284
HPRD ID		02872	09284
Ensembl ID		ENSG00000113088	ENSG00000039650
Uniprot IDs		P49863	Q96T60
PDB IDs		1MZA 1MZD	2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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