GZMK and TUBB3

Number of citations of the paper that reports this interaction (PubMedID 19059912)
18

Data Source:
BioGRID (enzymatic study)

		GZMK	TUBB3
Description		granzyme K	tubulin beta 3 class III
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GO Annotations	Cellular Component	Extracellular Region	Nucleus Cytoplasm Microtubule Lamellipodium Filopodium Axon Dendrite Growth Cone Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Netrin Receptor Binding
	Biological Process	Proteolysis Positive Regulation Of Apoptotic Process Negative Regulation Of Oxidoreductase Activity	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Axon Guidance Neuron Differentiation Netrin-activated Signaling Pathway Dorsal Root Ganglion Development
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs			Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases			Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Blood protein levels ( 30072576 29875488)	Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)
Interacting Genes		12 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TUBB3 UFD1 VCP	31 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDKN1A DDX39B EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 MAP7D3 MAPT MRPL28 MTCL1 MTDH PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE
Entrez ID		3003	10381
HPRD ID		02872	04044
Ensembl ID		ENSG00000113088	ENSG00000258947
Uniprot IDs		P49863	Q13509 Q53G92
PDB IDs		1MZA 1MZD	5IJ0 5IJ9 5JCO 6E7B 6S8L
Enriched GO Terms of Interacting Partners?
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