GUCY2C and PDZD3

Number of citations of the paper that reports this interaction (PubMedID 11950846)
19

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		GUCY2C	PDZD3
Description		guanylate cyclase 2C	PDZ domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Cytosol Plasma Membrane Brush Border Apical Junction Complex Apical Part Of Cell
	Molecular Function	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Toxic Substance Binding Natriuretic Peptide Receptor Activity Peptide Hormone Binding	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Ubiquitin-specific Protease Binding
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Digestion Response To Toxic Substance Intracellular Signal Transduction Regulation Of Cell Proliferation	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity
Pathways		Digestion Intestinal infectious diseases	Intestinal infectious diseases
Drugs		Linaclotide
Diseases
GWAS
Interacting Genes		3 interacting genes: GUCA2A PDZD3 SRC	18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C NLRX1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7
Entrez ID		2984	79849
HPRD ID		07529	06191
Ensembl ID		ENSG00000070019	ENSG00000172367
Uniprot IDs		P25092	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?
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