GRIN2B and PATJ

Number of citations of the paper that reports this interaction (PubMedID 9647694)
28

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		GRIN2B	PATJ
Description		glutamate ionotropic receptor NMDA type subunit 2B	PATJ crumbs cell polarity complex component
Image			No pdb structure
GO Annotations	Cellular Component	Cell Cytoplasm Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cell Junction Neuron Projection Postsynaptic Membrane Synaptic Membrane Postsynaptic Density Membrane	Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Zinc Ion Binding Ligand-gated Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding
	Biological Process	MAPK Cascade Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Multicellular Organism Development Brain Development Learning Or Memory Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Protein Heterotetramerization Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Positive Regulation Of Neuron Death Negative Regulation Of Dendritic Spine Maintenance Regulation Of NMDA Receptor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity	Intracellular Signal Transduction Bicellular Tight Junction Assembly
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Activated NTRK2 signals through FYN Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Glutamic Acid Atomoxetine Pentobarbital Secobarbital Pethidine Haloperidol Acamprosate Felbamate Gabapentin Memantine Phenobarbital Tenocyclidine Prasterone Taurine Milnacipran Acetylcysteine Ketobemidone Gavestinel Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)
Diseases
GWAS		Adventurousness ( 30643258) Aging (time to event) ( 21782286) Alzheimer's disease in hypertension ( 31055733) Brain structure (temporal lobe volume) ( 20197096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cognitive performance ( 19734545) Egg allergy (parent-of-origin effect) ( 29489655) General risk tolerance (MTAG) ( 30643258) Height ( 31562340) Immune reponse to smallpox (secreted IL-2) ( 22610502) Major depressive disorder ( 23377640) Ovarian reserve ( 22116950) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653) Total ventricular volume ( 21116278) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)
Interacting Genes		40 interacting genes: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 DLG1 DLG2 DLG3 DLG4 EPHB2 ERBIN EXOC4 EXOC7 FYN GRIN1 GRIN3A IL16 LIN7A LIN7B MAGI3 MIB2 PATJ PIK3CA PLCG1 PRKCA PRKCB PRKCG PRKN PTPN11 RACK1 SPTAN1 SRC SYNGAP1 TANC1	28 interacting genes: ADGRB1 ASIC3 CACNG2 CLDN1 CNKSR2 CRB3 CRIPT DDX18 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 MPP5 NLGN2 NRXN2 PARD3 PAX6 PRDM16 SCN4A SCN5A TJP3
Entrez ID		2904	10207
HPRD ID		00697	04434
Ensembl ID		ENSG00000273079	ENSG00000132849
Uniprot IDs		Q13224
PDB IDs		1S11 1S2S 2IPV 5EWJ 5EWL 5EWM
Enriched GO Terms of Interacting Partners?
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