ACAD9 and SEC61A1

		ACAD9	SEC61A1
Description		acyl-CoA dehydrogenase family member 9	SEC61 translocon subunit alpha 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Dendrite Mitochondrial Membrane	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Fatty-acyl-CoA Binding Long-chain-acyl-CoA Dehydrogenase Activity Protein Binding Very-long-chain-acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding Medium-chain-acyl-CoA Dehydrogenase Activity	Signal Sequence Binding Calcium Channel Activity Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Mitochondrial Respiratory Chain Complex I Assembly Medium-chain Fatty Acid Metabolic Process Oxidation-reduction Process	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Posttranslational Protein Targeting To Membrane, Translocation Response To Interferon-gamma Pronephric Nephron Development Protein Targeting To ER Calcium Ion Transmembrane Transport
Pathways		Complex I biogenesis	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Dental caries ( 23064961) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		5 interacting genes: H1-10 HMCES ISY1 SEC61A1 TMCC1	9 interacting genes: ACAD9 BAG6 CALM1 GET3 HSPA5 MLH1 SEC61G SERP1 TNF
Entrez ID		28976	29927
HPRD ID		12412	15316
Ensembl ID		ENSG00000177646	ENSG00000058262
Uniprot IDs		Q9H845	B3KME8 B3KNF6 P61619
PDB IDs
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