GIT1 and PXN

Number of citations of the paper that reports this interaction (PubMedID 10896954)
49

Data Source:
HPRD (in vivo)

		GIT1	PXN
Description		GIT ArfGAP 1	paxillin
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Focal Adhesion Membrane Calyx Of Held	Stress Fiber Cytosol Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium
	Molecular Function	GTPase Activator Activity Protein Binding Protein-containing Complex Binding Metal Ion Binding	Transcription Coregulator Activity Integrin Binding Protein Binding Beta-catenin Binding Vinculin Binding Protein Kinase Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Neuropilin Binding Metal Ion Binding
	Biological Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis	Muscle Contraction Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription
Pathways		Ephrin signaling Ephrin signaling Activation of RAC1 downstream of NMDARs	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Platelet count ( 29403010)
Interacting Genes		52 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	78 interacting genes: ABL1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK IMPDH2 ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SCARB1 SDC4 SELE SORBS1 SRC SYK TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL
Entrez ID		28964	5829
HPRD ID		06577	03937
Ensembl ID		ENSG00000108262	ENSG00000089159
Uniprot IDs		Q59FC3 Q9Y2X7	A0A140VJQ8 P49023
PDB IDs			1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6U4M 6U4N
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?