GIT1 and PMF1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		GIT1	PMF1
Description		GIT ArfGAP 1	polyamine modulated factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Focal Adhesion Membrane Calyx Of Held	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleoplasm Transcription Factor Complex Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding Protein-containing Complex Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding
	Biological Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis	Transcription By RNA Polymerase II Cell Cycle Chromosome Segregation Cell Division Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Ephrin signaling Ephrin signaling Activation of RAC1 downstream of NMDARs	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 30604766) Intracerebral hemorrhage ( 24656865) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Longevity (age >99th survival percentile) ( 31413261) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Stroke ( 29531354) White matter hyperintensity burden ( 25663218)
Interacting Genes		52 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	17 interacting genes: CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 GDF9 GIT1 HSP90AA1 KDM1A MED31 MIS12 NFE2L2 PTN SUGT1 TCP10L USHBP1
Entrez ID		28964	11243
HPRD ID		06577	11441
Ensembl ID		ENSG00000108262	ENSG00000160783
Uniprot IDs		Q59FC3 Q9Y2X7	Q6P1K2
PDB IDs			5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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