GRID2 and GRIK5

Number of citations of the paper that reports this interaction (PubMedID 12573530)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRID2	GRIK5
Description		glutamate ionotropic receptor delta type subunit 2	glutamate ionotropic receptor kainate type subunit 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Ionotropic Glutamate Receptor Complex Cell Junction Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Cell Nucleoplasm Endoplasmic Reticulum Plasma Membrane Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Ionotropic Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Scaffold Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity SH3 Domain Binding PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Ion Transmembrane Transport Cellular Protein Localization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Density Assembly Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly	Protein Retention In ER Lumen Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission Establishment Of Localization In Cell Excitatory Postsynaptic Potential Cellular Response To Glucose Stimulus
Pathways			Activation of Ca-permeable Kainate Receptor
Drugs		Glutamic Acid	Glutamic Acid
Diseases
GWAS		Coffee consumption ( 31046077) Intelligence (MTAG) ( 29326435) Manganese levels ( 26025379) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Post bronchodilator FEV1/FVC ratio ( 26634245)	Bipolar disorder ( 21771265)
Interacting Genes		10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4	8 interacting genes: DLG4 GOLM1 GPAA1 GRID2 GRIK2 GRIK3 LRSAM1 MLF1
Entrez ID		2895	2901
HPRD ID		06781	02614
Ensembl ID		ENSG00000152208	ENSG00000105737
Uniprot IDs		O43424	Q16478
PDB IDs		5KC8 5KCA
Enriched GO Terms of Interacting Partners?
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