TBXA2R and GNAS

Number of citations of the paper that reports this interaction (PubMedID 15782186)
112

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TBXA2R	GNAS
Description		thromboxane A2 receptor	GNAS complex locus
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GO Annotations	Cellular Component	Acrosomal Vesicle Cell Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Cytosol Heterotrimeric G-protein Complex Membrane Apical Plasma Membrane Dendrite Extracellular Exosome
	Molecular Function	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	G Protein-coupled Receptor Binding GTPase Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding Adenylate Cyclase Activator Activity G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Positive Regulation Of Blood Coagulation Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Tissue Homeostasis Endochondral Ossification Energy Reserve Metabolic Process DNA Methylation Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Post-embryonic Body Morphogenesis Positive Regulation Of Catalytic Activity Skin Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Developmental Growth Embryonic Cranial Skeleton Morphogenesis Cartilage Development Bone Development Platelet Aggregation Genetic Imprinting Positive Regulation Of Cold-induced Thermogenesis Regulation Of Parathyroid Hormone Secretion
Pathways		Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor	Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production
Drugs		Ridogrel Seratrodast	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
Diseases			Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy Pseudohypoparathyroidism Progressive osseous heteroplasia (POH)
GWAS			Birth weight ( 31043758) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582) Creatinine levels ( 29124443) Diastolic blood pressure ( 21909115 29403010 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31152163 31015462 29124443) Height ( 31562340) Hypertension ( 21909115) Hyperuricemia ( 29124443) Mean arterial pressure ( 29403010) Platelet distribution width ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Serum uric acid levels ( 29124443) Sulfasalazine-induced agranulocytosis ( 28762467) Systolic blood pressure ( 21909115 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 30297969) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 26785701)
Interacting Genes		22 interacting genes: GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 NME2 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L YWHAZ	35 interacting genes: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CHEK2 CRHR1 EGFR GCGR GLP1R GNB1 GNGT1 HTR6 LHB LHCGR MTNR1B NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1
Entrez ID		6915	2778
HPRD ID		01768	00761
Ensembl ID		ENSG00000006638	ENSG00000087460
Uniprot IDs		P21731 Q05C92 Q0VAB0	A0A0S2Z3H8 A0A0S2Z3S5 A0A590UJF0 B0AZR9 O95467 P63092 P84996 Q14455 Q5FWY2 Q5JWD1 Q5JWF2
PDB IDs		1LBN	5G53 5UZ7 5VAI 6AU6 6B3J 6E3Y 6E67 6EG8 6GDG 6NI3 6NIY
Enriched GO Terms of Interacting Partners?
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